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Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study.
The Journal of Antibiotics ( IF 2.1 ) Pub Date : 2020-06-01 , DOI: 10.1038/s41429-020-0333-2
Jessica Vaca 1 , Francisco Salazar 1 , Aurelio Ortiz 1 , Estibaliz Sansinenea 1
Affiliation  

Six known indole alkaloid derivatives have been isolated for the first time from Bacillus thuringiensis and Bacillus velezensis strains, all of them as building blocks for the synthesis of larger natural products. Their structure was elucidated by a complete spectroscopy. Their biological activities were tested against some Gram-positive and Gram-negative bacteria and three phytopathogenic fungi which cause diseases in important crops, such as Moniliophthora roreri, the causal agent of cacao disease. The results indicated that some compounds had modest antibacterial activity; however, some of them had strong antifungal activity against the probed fungi. This antifungal activity of these compounds has not been reported.



中文翻译:

苏云金芽孢杆菌和velezensis天然产物的组成部分吲哚生物碱衍生物及其抗菌和抗真菌活性的研究。

苏云金芽孢杆菌velezensis菌株中首次分离出六个已知的吲哚生物碱衍生物,它们都是合成较大天然产物的基础。通过完整的光谱学阐明了它们的结构。测试了它们对某些革兰氏阳性和革兰氏阴性细菌以及三种植物病原真菌的生物学活性,这些细菌引起重要农作物的疾病,如可可病的病原体罗氏莫里氏菌。结果表明,某些化合物具有适度的抗菌活性。然而,其中一些对所探查的真菌具有很强的抗真菌活性。这些化合物的这种抗真菌活性尚未见报道。

更新日期:2020-06-01
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