Gene transcription is counterbalanced by messenger RNA decay processes that regulate transcript quality and quantity. We show here that the evolutionarily conserved DHH1/DDX6-like RNA hellicases of Arabidopsis thaliana control the ephemerality of a subset of cellular mRNAs. These RNA helicases co-localize with key markers of processing bodies and stress granules and contribute to their subcellular dynamics. They function to limit the precocious accumulation and ribosome association of stress-responsive mRNAs involved in auto-immunity and growth inhibition under non-stress conditions. Given the conservation of this RNA helicase subfamily, they may control basal levels of conditionally regulated mRNAs in diverse eukaryotes, accelerating responses without penalty.

基因转录通过调节转录物质量和数量的信使RNA衰变过程来抵消。我们在这里显示拟南芥的进化上保守的DHH1 / DDX6样RNA hellases控制着细胞mRNA子集的星历。这些RNA解旋酶与加工体和应激颗粒的关键标记共定位，并有助于其亚细胞动力学。它们的作用是限制在非应激条件下参与自身免疫和生长抑制的应激反应mRNA的早熟积累和核糖体缔合。考虑到该RNA解旋酶亚家族的保守性，它们可以控制各种真核生物中条件调节的mRNA的基础水平，从而加速反应而不受惩罚。