Abstract

CeO₂/CuO@nitrogen graphene quantum dots@NH₂ nanocomposite has been used as an efficient catalyst for the preparation of benzodiazepines by multi-component reactions of 1,2-phenylenediamine with dimedone and aromatic aldehydes or Meldrum’s acid and isocyanides. The best results were obtained in the presence of 5 mg of CeO₂/CuO@N-GQDs@NH₂ at room temperature. The catalyst has been characterized by FT-IR (Fourier-transform infrared spectroscopy), SEM (scanning electron microscope), XRD (X-ray powder diffraction), EDS (energy-dispersive X-ray spectroscopy), TGA (thermogravimetric analysis), BET (Brunauer–Emmett–Teller), XPS (X-ray photoelectron spectroscopy) and VSM (vibrating-sample magnetometer). Experimental simplicity, wide range of products, excellent yields in short reaction times, reusability of the catalyst and low catalyst loading are some of the substantial features of this method.

摘要

CeO ₂ /CuO@氮石墨烯量子点@NH ₂纳米复合材料已被用作通过1,2-苯二胺与二甲酮和芳香醛或Meldrum酸和异氰化物的多组分反应制备苯二氮卓类药物的高效催化剂。_{在存在 5 mg CeO 2} /CuO@N-GQDs@NH ₂的情况下获得了最佳结果在室温下。该催化剂已通过FT-IR（傅里叶变换红外光谱）、SEM（扫描电子显微镜）、XRD（X射线粉末衍射）、EDS（能量色散X射线光谱）、TGA（热重分析）、 BET（Brunauer-Emmett-Teller）、XPS（X 射线光电子能谱）和 VSM（振动样品磁力计）。实验简单、产品范围广、反应时间短、催化剂的可重复使用性和催化剂负载低是该方法的一些重要特征。