Synthesis of functionalized 2-pyridone derivatives from thiazolo[3,2-a]pyridine-6-carbohydrazides or tetrahydroimidazo[1,2-a]pyridine-6-carbohydrazides was developed using acetic acid as solvent at 70°C. Various carbohydrazides could be applied to this protocol, and the desired 2-pyridone products were isolated in excellent yields by simple filtration. This method has several additional advantages, such as simple operation, mild reaction conditions, simple work up, easy product isolation, and preparation of potentially bioactive compounds. GRAPHICAL ABSTRACT

中文翻译：

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高度官能化氢吡啶酮的合成：thiazolo[3,2-a]pyridin-5-one-6-carbohydrazones 和四氢咪唑并[1,2-a]pyridin-5-one-2-carbohydrazones

在 70°C 下使用乙酸作为溶剂，开发了由噻唑并[3,2-a]吡啶-6-碳酰肼或四氢咪唑并[1,2-a]吡啶-6-碳酰肼合成官能化的2-吡啶酮衍生物。各种碳酰肼可以应用于该协议，并且通过简单的过滤以优异的产率分离了所需的 2-吡啶酮产品。该方法还有其他几个优点，例如操作简单、反应条件温和、后处理简单、产品易于分离以及制备具有潜在生物活性的化合物。图形概要