Objective

Currently published papers regarding the relationship between integrin alpha V (ITGAV) gene polymorphisms and rheumatoid arthritis (RA) are contradictory. The aim of this meta-analysis was to evaluate the associations between the ITGAV gene polymorphisms and RA risk.

Methods

Comprehensive literature search based on four electronic databases was applied to retrieve all related data. Two independent reviewers screened each article for eligibility according to the predetermined inclusion criteria. Pooled odds ratios (ORs) and 95% confidence intervals (95% CIs) were used to assess associations between ITGAV gene polymorphisms and RA.

Results

Six articles involving 5794 RA patients and 5297 healthy controls were included in this meta-analysis. The combined data indicated that rs3911238, rs3738919, rs3768777, and rs10174098 in ITGAV gene were not associated with RA risk in the overall population. However, stratification analysis by ethnicity suggested that rs3768777 was related with risk of RA among Caucasian population (OR 3.51, 95%CI 2.06, 5.97; P < 0.0001), but not among Asian population (OR 1.06, 95%CI 0.67, 1.69; P = 0.81).

Conclusions

Our meta-analysis confirmed that the ITGAV gene rs3768777 polymorphisms might be a risk factor among Caucasians. However, larger-scale studies in Caucasian population are still warranted to confirm the findings of our study.

中文翻译：

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ITGAV 多态性与类风湿性关节炎风险的关联：来自荟萃分析的证据。

目标

目前发表的关于整合素α V (ITGAV) 基因多态性与类风湿性关节炎 (RA) 之间关系的论文是相互矛盾的。该荟萃分析的目的是评估 ITGAV 基因多态性与 RA 风险之间的关联。

方法

应用基于四个电子数据库的综合文献检索来检索所有相关数据。两名独立审稿人根据预先确定的纳入标准筛选了每篇文章的资格。合并优势比 (OR) 和 95% 置信区间 (95% CI) 用于评估 ITGAV 基因多态性与 RA 之间的关联。

结果

该荟萃分析共纳入 6 篇文章，涉及 5794 名 RA 患者和 5297 名健康对照。综合数据表明，ITGAV 基因中的 rs3911238、rs3738919、rs3768777 和 rs10174098 与总体人群中的 RA 风险无关。然而，种族分层分析表明，rs3768777 与白种人人群中 RA 的风险相关（OR 3.51, 95%CI 2.06, 5.97; P < 0.0001），但与亚洲人群无关（OR 1.06, 95%CI 0.67, 1.69; P = 0.81）。

结论

我们的荟萃分析证实，ITGAV 基因 rs3768777 多态性可能是白种人的危险因素。然而，仍然需要对白种人进行更大规模的研究来证实我们的研究结果。