Introduction

The oral route is one of the most attractive modalities of drug delivery, providing easy administration and great patient compliance. However, enzymatic degradation and physiological barriers in the gastrointestinal tract are still unsolved obstacles for many drugs. The physico-chemical characteristics of biopharmaceuticals and the resulting low stability and poor penetration capacity across biological barriers represent current challenges that need to be overcome in oral delivery. The use of polyaminoacids and polypeptides, including cell-penetrating peptides as delivery carriers is an attractive strategy to improve the oral bioavailability of therapeutics. These biopolymers are positioned as potential biomaterials due to their low toxicity and their capacity to enhance the stability of biomolecules while increasing their transport through biological barriers.

Areas covered

In this review, we present an update of the current approaches and strategies carried out in the design of nanosystems and penetration-enhancing oral delivery strategies based on polyaminoacids.

Expert opinion

Polyaminoacids and polypeptides are functional and versatile biomaterials which have received significant attention for the design of oral drug delivery platforms. Even though only a few prototypes have yet entered clinical trials, a number of promising strategies can be found in advanced preclinical investigation for the delivery of biopharmaceuticals.

中文翻译：

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基于聚氨基酸的纳米载体：综述口服药物的最新候选药物。

介绍

口服途径是最有吸引力的药物递送方式之一，提供了易于管理和良好的患者依从性。然而，胃肠道的酶促降解和生理障碍仍然是许多药物尚未解决的障碍。生物药物的物理化学特性以及由此产生的稳定性低和穿透生物屏障的渗透能力差代表了当前的挑战，需要通过口服给药来克服。使用聚氨基酸和多肽，包括穿透细胞的肽作为递送载体，是提高治疗剂的口服生物利用度的有吸引力的策略。

覆盖区域

在这篇综述中，我们介绍了在纳米系统设计和基于聚氨基酸的渗透增强口服给药策略设计中进行的当前方法和策略的更新。

专家意见

聚氨基酸和多肽是功能性且用途广泛的生物材料，在口服药物递送平台的设计中受到了极大的关注。尽管只有少数原型已经进入临床试验，但在先进的临床前研究中，可以找到许多有前途的策略来运送生物药物。