Here, we reported nicotinamide (NIC), a long-known vitamin, was revealed in fact to be a highly polymorphic compound with nine solved single-crystal structures by performing melt crystallization. A CSP calculation successfully identified all six Z’ = 1 and 2 experimental structures. Melt crystallization has turned out to be an efficient tool for exploring polymorphic landscape, especially in regions inaccessbile by solution crystallization.

中文翻译：

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烟酰胺：熔融结晶和晶体结构预测揭示了七个新的多晶型结构。

在这里，我们报道了一种已知的长期存在的维生素-烟酰胺（NIC）实际上是一种高度多态的化合物，通过进行熔融结晶具有9个已解决的单晶结构。CSP计算成功地确定了所有六个Z'= 1和2个实验结构。熔体结晶已被证明是探索多晶景观的有效工具，尤其是在溶液结晶无法进入的地区。