Intoxication cases associated with the novel designer drug 3',4'-methylenedioxy-α-pyrrolidinohexanophenone and studies on its human metabolism using high-resolution mass spectrometry.,Drug Testing and Analysis

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Intoxication cases associated with the novel designer drug 3',4'-methylenedioxy-α-pyrrolidinohexanophenone and studies on its human metabolism using high-resolution mass spectrometry.
Drug Testing and Analysis ( IF 2.6 ) Pub Date : 2020-07-01 , DOI: 10.1002/dta.2869
Marcel Grapp ₁ , Christoph Kaufmann ₁ , Hannes M Schwelm ₂ , Merja A Neukamm ₂ , Sabine Blaschke ₃ , Abass Eidizadeh ₄

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Among the increasing number of new psychoactive substances, 3′,4′‐methylenedioxy‐α‐pyrrolidinohexanophenone (MDPHP) belongs to the group of synthetic cathinones, which are the derivatives of the naturally occurring compound cathinone, the main psychoactive ingredient in the khat plant. Currently, only limited data are available for MDPHP, and no information is available on its human metabolism. We describe the toxicological investigation of nine cases associated with the use of MDPHP during the period February–June 2019. Serum MDPHP concentrations showed a high variability ranging from 3.3 to 140 ng/mL (mean 30.3 ng/mL and median 16 ng/mL). Intoxication symptoms of the described cases could not be explained by the abuse of MDPHP alone because in all cases the co‐consumption of other psychotropic drugs with frequent occurrence of opiates and benzodiazepines could be verified. Therefore, the patients showed different clinical symptoms, including aggressive behaviour, delayed physical response, loss of consciousness and coma. Liquid chromatography–high‐resolution mass spectrometry was successfully used to investigate the human in vivo metabolism of MDPHP using authentic human urine samples. The metabolism data for MDPHP were further substantiated by the analysis of human urine using gas chromatography–mass spectrometry (GC–MS, a widely used systematic toxicological analysis method appropriate for the toxicological detection of MDPHP intake), which revealed the presence of seven phase I metabolites and three phase II metabolites as glucuronides. GC‐MS spectral data for MDPHP and metabolites are provided. The identified metabolite pattern corroborates the principal metabolic pathways of α‐pyrrolidinophenones in humans.

中文翻译：

与新型设计药物 3',4'-亚甲二氧基-α-吡咯烷基己苯酮相关的中毒案例及其使用高分辨率质谱法对其人体代谢的研究。

在越来越多的新型精神活性物质中，3',4'-亚甲二氧基-α-吡咯烷基己苯酮 (MDPHP) 属于合成卡西酮类，它是天然化合物卡西酮的衍生物，卡塔叶植物中的主要精神活性成分. 目前，MDPHP 的可用数据有限，并且没有关于其人体新陈代谢的信息。我们描述了 2019 年 2 月至 6 月期间与使用 MDPHP 相关的 9 个病例的毒理学调查。血清 MDPHP 浓度显示出高变异性，范围为 3.3 至 140 ng/mL（平均 30.3 ng/mL 和中值 16 ng/mL） . 所描述病例的中毒症状不能仅用 MDPHP 的滥用来解释，因为在所有病例中，都可以证实与其他精神药物的共同食用以及频繁出现的阿片类药物和苯二氮卓类药物。因此，患者表现出不同的临床症状，包括攻击行为、身体反应迟缓、意识丧失和昏迷。液相色谱-高分辨质谱成功地用于使用真实的人类尿液样本研究 MDPHP 的人体体内代谢。MDPHP 的代谢数据通过使用气相色谱-质谱法（GC-MS，一种广泛使用的系统毒理学分析方法，适用于 MDPHP 摄入量的毒理学检测）对人尿的分析得到进一步证实，这揭示了存在七种 I 相代谢物和三种 II 相代谢物作为葡糖苷酸。提供了 MDPHP 和代谢物的 GC-MS 光谱数据。鉴定的代谢物模式证实了人类 α-吡咯烷苯酮的主要代谢途径。

更新日期：2020-07-01

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