Inorganic Porous Nanoparticles for Drug Delivery in Antitumoral Therapy,Biotechnology Journal

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Inorganic Porous Nanoparticles for Drug Delivery in Antitumoral Therapy
Biotechnology Journal ( IF 3.2 ) Pub Date : 2020-06-01 , DOI: 10.1002/biot.202000150
Jorge Parra-Nieto ₁ , María Amor García Del Cid ₁ , Iñigo Aguirre de Cárcer ₁ , Alejandro Baeza ₁

Affiliation

The use of nanoparticles in oncology to deliver chemotherapeutic agents has received considerable attention in the last decades due to their tendency to be passively accumulated in solid tumors. Besides this remarkable property, the surface of these nanocarriers can be decorated with targeting moieties capable to recognize malignant cells which lead to selective nanoparticle uptake mainly in the diseased cells, without affecting the healthy ones. Among the different nanocarriers which have been developed with this purpose, inorganic porous nanomaterials constitute some of the most interesting due to their unique properties such as excellent cargo capacity, high biocompatibility and chemical, thermal and mechanical robustness, among others. Additionally, these materials can be engineered to present an exquisite control in the drug release behavior placing stimuli‐responsive pore‐blockers or sensitive hybrid coats on their surface. Herein, the recent advances developed in the use of porous inorganic nanomedicines will be described in order to provide an overview of their huge potential in the look out of an efficient and safe therapy against this complex disease. Porous inorganic nanoparticles have been designed to be accumulated in tumoral tissues; once there to recognize the target cell and finally, to release their payload in a controlled manner.

中文翻译：

无机多孔纳米颗粒在抗肿瘤治疗中的药物递送

由于纳米粒子倾向于在实体瘤中被动累积，因此在肿瘤学中使用纳米粒子来输送化学治疗剂在近几十年来受到了广泛的关注。除了这种显着的特性，这些纳米载体的表面还可以用靶向部分修饰，这些靶向部分能够识别恶性细胞，从而导致主要在患病细胞中选择性摄取纳米颗粒，而不影响健康细胞。在为此目的而开发的不同纳米载体中，无机多孔纳米材料由于其独特的特性（例如出色的载货量，高生物相容性以及化学，热和机械强度）而构成了一些最令人感兴趣的材料。另外，可以对这些材料进行设计，使其对药物的释放行为具有精确的控制，从而在其表面上放置刺激性毛孔阻断剂或敏感的杂化涂层。在此，将描述在使用多孔无机纳米药物方面开发的最新进展，以便概述其在针对这种复杂疾病的有效且安全的治疗方法方面的巨大潜力。已经设计了多孔无机纳米颗粒在肿瘤组织中积累；一旦在那里识别目标小区，最后以受控方式释放它们的有效载荷。将描述使用多孔无机纳米药物的最新进展，以概述其在针对这种复杂疾病的有效且安全的治疗方法方面的巨大潜力。已经设计了多孔无机纳米颗粒在肿瘤组织中积累；一旦在那里识别目标小区，最后以受控方式释放它们的有效载荷。将描述使用多孔无机纳米药物的最新进展，以概述其在针对这种复杂疾病的有效且安全的治疗方法方面的巨大潜力。已经设计了多孔无机纳米颗粒在肿瘤组织中积累；一旦在那里识别目标小区，最后以受控方式释放它们的有效载荷。

更新日期：2020-06-01

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