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Intraluminal nutrients acutely strengthen rat intestinal MRP2 barrier function by a glucagon-like peptide-2-mediated mechanism.
Acta Physiologica ( IF 5.6 ) Pub Date : 2020-06-01 , DOI: 10.1111/apha.13514 Guillermo N Tocchetti 1, 2 , Camila J Domínguez 1 , Felipe Zecchinati 1 , Maite R Arana 1 , Juan P Rigalli 2 , María L Ruiz 1 , Silvina S M Villanueva 1 , Aldo D Mottino 1
Acta Physiologica ( IF 5.6 ) Pub Date : 2020-06-01 , DOI: 10.1111/apha.13514 Guillermo N Tocchetti 1, 2 , Camila J Domínguez 1 , Felipe Zecchinati 1 , Maite R Arana 1 , Juan P Rigalli 2 , María L Ruiz 1 , Silvina S M Villanueva 1 , Aldo D Mottino 1
Affiliation
MRP2 is an intestinal ABC transporter that prevents the absorption of dietary xenobiotics. The aims of this work were: (1) to evaluate whether a short‐term regulation of intestinal MRP2 barrier function takes place in vivo after luminal incorporation of nutrients and (2) to explore the underlying mechanism.
中文翻译:
腔内营养物质通过胰高血糖素样肽 2 介导的机制急性增强大鼠肠道 MRP2 屏障功能。
MRP2 是一种肠道 ABC 转运蛋白,可防止膳食异生素的吸收。这项工作的目的是:(1)评估肠道 MRP2 屏障功能的短期调节是否在管腔内掺入营养物质后在体内发生;(2)探索潜在机制。
更新日期:2020-06-01
中文翻译:
腔内营养物质通过胰高血糖素样肽 2 介导的机制急性增强大鼠肠道 MRP2 屏障功能。
MRP2 是一种肠道 ABC 转运蛋白,可防止膳食异生素的吸收。这项工作的目的是:(1)评估肠道 MRP2 屏障功能的短期调节是否在管腔内掺入营养物质后在体内发生;(2)探索潜在机制。