Impurity profiling of alfentanil hydrochloride by liquid chromatography/quadrupole time-of-flight high-resolution mass spectrometric techniques for drug enforcement.,Rapid Communications in Mass Spectrometry

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Impurity profiling of alfentanil hydrochloride by liquid chromatography/quadrupole time-of-flight high-resolution mass spectrometric techniques for drug enforcement.
Rapid Communications in Mass Spectrometry ( IF 1.8 ) Pub Date : 2020-06-01 , DOI: 10.1002/rcm.8847
Ye Wang _{1,

2} , Lei Xu _{1,

2} , Yu-Ting Lu _{1,

2} , Fan-Mei Sun _{1,

2} , Dong-Feng Wu _{1,

2} , Jing-Qi Wang _{1,

2} , Bin Di _{1,

2} , Hui Xu ₁ , Tai-Jun Hang _{1,

2} , Min Song _{1,

2}

Affiliation

Fentanyl and its analogues play an important role in hospital and clinic as anesthetic. However, illicitly manufactured fentanyl as well as the new psychoactive substances (NPS) account for 30% of all deaths in the United States. Since fentanyl derivatives and NPS are designed to produce similar effects, their related substances are similar or even have same active groups. A comprehensive analysis of the related substances of alfentanil hydrochloride can provide a basis for the identification and supervision of fentanyl derivatives and NPS.

中文翻译：

通过液相色谱/四极杆飞行时间高分辨率质谱技术对盐酸阿芬太尼进行杂质分析，以进行药物执行。

芬太尼及其类似物作为麻醉剂在医院和诊所中起着重要作用。但是，非法制造的芬太尼以及新型精神活性物质（NPS）占美国所有死亡人数的30％。由于芬太尼衍生物和NPS旨在产生相似的效果，因此它们的相关物质相似，甚至具有相同的活性基团。对盐酸阿芬太尼相关物质的综合分析可为芬太尼衍生物和NPS的鉴定和监督提供依据。

更新日期：2020-06-01

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