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Lipid-lowering effect of Pinus sp. sawdust and Pycnoporus sanguineus mycelium in streptozotocin-induced diabetic rats.
Journal of Food Biochemistry ( IF 4 ) Pub Date : 2020-06-01 , DOI: 10.1111/jfbc.13247
Giovana Rech 1, 2 , Larissa Lopes da Silva 1 , Keoma da Silva 2 , Tuani Mendes Silva 3 , Roselei Claudete Fontana 1 , Mirian Salvador 3 , Matheus Parmegiani Jahn 2 , Marli Camassola 1
Affiliation  

The purpose of this study was to investigate the effect of diet supplementations on biochemical, hematological, and redox metabolism parameters in streptozotocin‐induced diabetic rats. Healthy male Wistar rats and streptozotocin‐induced diabetic rats were provided diets supplemented with 20% of Pinus sp. sawdust or Pycnoporus sanguineus mycelium for 4 weeks. Diabetic rats treated with both Pinus sp. sawdust‐ and P. sanguineus mycelium‐supplemented diets presented a significant decrease in non‐HDL cholesterol of 38.43% and 33.53% and triglycerides of 70.03% and 69.81%, respectively, compared to diabetic control. As far as we know, this is the first report of a significant decrease in serum lipids attributed to these supplementations. Even though with the alterations in hematological and redox metabolism parameters related to these diet treatments, our data suggest that Pinus sp. sawdust and Pycnoporus sanguineus mycelium could be a useful a diet supplement to control diabetic dyslipidemia in animals.

中文翻译:

松树的降血脂作用。链脲佐菌素诱发的糖尿病大鼠中的木屑和碧萝P菌丝体。

这项研究的目的是研究膳食补充剂对链脲佐菌素诱导的糖尿病大鼠生化,血液学和氧化还原代谢参数的影响。向健康的雄性Wistar大鼠和链脲佐菌素诱导的糖尿病大鼠提供补充20%Pinus sp。的饮食。锯末或Pycnoporus sanguineus菌丝体持续4周。两种Pinus sp。处理的糖尿病大鼠。锯末和血红假单胞菌与糖尿病对照组相比,补充了菌丝的饮食显着降低了非高密度脂蛋白胆固醇的38.43%和33.53%,甘油三酸酯的70.03%和69.81%。据我们所知,这是首次归因于这些补充剂的血脂显着下降的报道。即使与这些饮食疗法有关的血液学和氧化还原代谢参数发生了变化,我们的数据也表明松树属。木屑和碧萝P菌丝体可能是控制动物糖尿病性血脂异常的有效饮食补品。
更新日期:2020-06-01
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