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A comparison of the effects of Stevia extract and metformin on metabolic syndrome indices in rats fed with a high-fat, high-sucrose diet.
Journal of Food Biochemistry ( IF 3.5 ) Pub Date : 2020-06-01 , DOI: 10.1111/jfbc.13242
Tahereh Ranjbar 1 , Ali Akbar Nekooeian 2 , Nader Tanideh 2, 3 , Omid Koohi-Hosseinabadi 4 , Seyed Jalil Masoumi 1, 5 , Sasan Amanat 6 , Negar Azarpira 7 , Ahmad Monabati 8
Affiliation  

The beneficial effects of Stevia on metabolic indices have been studied in recent years. However, controversial results emphasize the need for further investigation. We aimed to examine and compare the effects of Stevia’s hydroalcoholic extract with two dosages (200, 400 mg/kg) with those of metformin (100 mg/kg) on metabolic syndrome (MetS) indices of rats fed with a high‐fat, high‐sucrose diet (HFHS). It was found that both Stevia extract and metformin could prevent the adverse effects of a HFHS on lipid profile, liver enzymes, total antioxidant capacity (TAC), and histopathologic factors. Except for the finding that metformin showed a greater potential to alleviate insulin resistance than did Stevia extract, no significant difference was observed between the rats receiving metformin or Stevia extract. In addition, using a high treatment dosage of Stevia extract did not lead to better results than a low dosage. Collectively, the efficacy of Stevia extracts to modify metabolic, oxidative, and histopathological indices in a MetS model was comparable to that of the metformin.

中文翻译:

甜菊提取物和二甲双胍对高脂,高蔗糖饮食喂养的大鼠代谢综合症指标的作用比较。

近年来,已经研究了甜叶菊对代谢指标的有益作用。但是,有争议的结果强调需要进一步调查。我们旨在检查和比较两种剂量(200、400 mg / kg)和二甲双胍(100 mg / kg)的甜叶菊水醇提取物对高脂高脂饮食大鼠代谢综合征(MetS)指数的影响蔗糖饮食(HFHS)。发现甜叶菊提取物和二甲双胍均可预防HFHS对血脂,肝酶,总抗氧化能力(TAC)和组织病理学因素的不利影响。除了发现二甲双胍比甜菊提取物具有更大的缓解胰岛素抵抗的潜力外,在接受二甲双胍或甜菊提取物的大鼠之间未观察到显着差异。此外,使用高处理量的甜菊提取物并不能获得比低处理量更好的结果。总体而言,甜菊提取物在MetS模型中修饰代谢,氧化和组织病理学指标的功效与二甲双胍相当。
更新日期:2020-06-01
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