Cardioprotective activity of ethanolic extract of Echinophora cinerea against aluminum phosphide poisoning in rats.,Journal of Food Biochemistry

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Cardioprotective activity of ethanolic extract of Echinophora cinerea against aluminum phosphide poisoning in rats.
Journal of Food Biochemistry ( IF 3.5 ) Pub Date : 2020-06-01 , DOI: 10.1111/jfbc.13300
Sara Haydari ₁ , Afshin Nazari ₁ , Maryam Moghimian ₂ , Mehrnoosh Sedighi ₃ , Saber Ghaderpour ₄

Affiliation

Rice tablet, also known as aluminum phosphide (ALP), is a nonorganic material used as an insecticide and rodenticide in the storage and transportation of grains. Phosphine gas, released from the chemical material, in contact with humidity and weak acid, can induce poisoning and death. This study was conducted to investigate the effect of ethanol extract of Echinophora cinerea leaves on ALP poisoning in heart in rats. In this study, factors such as blood pressure, heart rate, electrocardiography, and biochemical biomarkers of oxidative stress of cardiac tissue were evaluated. The use of Echinophora extract at a dose of 200 mg per/kg primarily improved bradycardia, hypotension, and cardiac conduction. Echinophora extract at a dose of 400 mg could protect body against oxidative stress. It seems that Echinophora extract has significant clinical positive effects that can be employed in treatment protocols of acute poisoning associated with ALP.

中文翻译：

灰棘鱼乙醇提取物对大鼠磷化铝中毒的心脏保护作用。

大米片也称为磷化铝（ALP），是一种非有机材料，在谷物的储存和运输中用作杀虫剂和灭鼠剂。从化学物质中释放出来的磷化氢气体与湿气和弱酸接触会导致中毒和死亡。这项研究旨在研究灰棘叶乙醇提取物对大鼠心脏ALP中毒的影响。在这项研究中，评估了诸如血压，心率，心电图和心脏组织氧化应激的生化生物标志物等因素。以200 mg / kg的剂量使用E草提取物可改善心动过缓，低血压和心脏传导。棘皮动物提取物的剂量为400 mg可以保护人体免受氧化应激。chin草提取物似乎具有显着的临床积极作用，可用于与ALP相关的急性中毒的治疗方案。

更新日期：2020-06-01

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