ENIGMA brain injury: Framework, challenges, and opportunities,Human Brain Mapping

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ENIGMA brain injury: Framework, challenges, and opportunities
Human Brain Mapping ( IF 3.5 ) Pub Date : 2020-06-01 , DOI: 10.1002/hbm.25046
Emily L Dennis _{1,

2,

3} , David Baron ₄ , Brenda Bartnik-Olson ₅ , Karen Caeyenberghs ₆ , Carrie Esopenko ₇ , Frank G Hillary _{8,

9} , Kimbra Kenney _{10,

11} , Inga K Koerte _{12,

13} , Alexander P Lin ₁₄ , Andrew R Mayer _{15,

16} , Stefania Mondello ₁₇ , Alexander Olsen _{18,

19} , Paul M Thompson _{3,

20} , David F Tate _{1,

2} , Elisabeth A Wilde _{1,

2}

Affiliation

Department of Neurology, University of Utah School of Medicine, Salt Lake City, Utah, USA.
George E. Wahlen Veterans Affairs Medical Center, Salt Lake City, Utah, USA.
Imaging Genetics Center, Stevens Neuroimaging & Informatics Institute, Keck School of Medicine of USC, Marina del Rey, California, USA.
Western University of Health Sciences, Pomona, California, USA.
Department of Radiology, Loma Linda University Medical Center, Loma Linda, California, USA.
Cognitive Neuroscience Unit, School of Psychology, Deakin University, Burwood, Victoria, Australia.
Department of Rehabilitation and Movement Sciences, Rutgers Biomedical Health Sciences, Newark, New Jersey, USA.
Department of Psychology, Pennsylvania State University, University Park, Pennsylvania, USA.
Social Life and Engineering Sciences Imaging Center, University Park, Pennsylvania, USA.
Department of Neurology, Uniformed Services University of the Health Sciences, Bethesda, Maryland, USA.
National Intrepid Center of Excellence, Walter Reed National Military Medical Center, Bethesda, Maryland, USA.
Psychiatry Neuroimaging Laboratory, Brigham and Women's Hospital, Boston, Massachusetts, USA.
Department of Child and Adolescent Psychiatry, Psychosomatics and Psychotherapy, Ludwig-Maximilians-Universität, Munich, Germany.
Center for Clinical Spectroscopy, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA.
Mind Research Network, Albuquerque, New Mexico, USA.
Department of Neurology and Psychiatry, University of New Mexico School of Medicine, Albuquerque, New Mexico, USA.
Department of Biomedical and Dental Sciences and Morphofunctional Imaging, University of Messina, Messina, Italy.
Department of Psychology, Norwegian University of Science and Technology, Trondheim, Norway.
Department of Physical Medicine and Rehabilitation, St. Olavs Hospital, Trondheim University Hospital, Trondheim, Norway.
Department of Neurology, Pediatrics, Psychiatry, Radiology, Engineering, and Ophthalmology, University of Southern California (USC), Los Angeles, California, USA.

Traumatic brain injury (TBI) is a major cause of disability worldwide, but the heterogeneous nature of TBI with respect to injury severity and health comorbidities make patient outcome difficult to predict. Injury severity accounts for only some of this variance, and a wide range of preinjury, injury-related, and postinjury factors may influence outcome, such as sex, socioeconomic status, injury mechanism, and social support. Neuroimaging research in this area has generally been limited by insufficient sample sizes. Additionally, development of reliable biomarkers of mild TBI or repeated subconcussive impacts has been slow, likely due, in part, to subtle effects of injury and the aforementioned variability. The ENIGMA Consortium has established a framework for global collaboration that has resulted in the largest-ever neuroimaging studies of multiple psychiatric and neurological disorders. Here we describe the organization, recent progress, and future goals of the Brain Injury working group.

中文翻译：

ENIGMA 脑损伤：框架、挑战和机遇

创伤性脑损伤 (TBI) 是世界范围内造成残疾的主要原因，但 TBI 在损伤严重程度和健康合并症方面的异质性使得患者的结果难以预测。损伤严重程度只是造成这种差异的一部分原因，损伤前、损伤相关和损伤后的多种因素可能会影响结果，例如性别、社会经济地位、损伤机制和社会支持。该领域的神经影像研究通常受到样本量不足的限制。此外，轻度创伤性脑损伤或反复亚脑震荡影响的可靠生物标志物的开发进展缓慢，部分原因可能是由于损伤和上述变异性的微妙影响。ENIGMA 联盟建立了一个全球合作框架，促成了针对多种精神和神经系统疾病的有史以来最大规模的神经影像学研究。在此，我们介绍脑损伤工作组的组织、近期进展和未来目标。

更新日期：2020-06-01

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