Interferon (IFN)-stimulated gene product 15 (ISG15) is a ubiquitin-like protein critical for the control of microbial infections. ISG15 appears to serve a wide variety of functions, which regulate multiple cellular responses contributing to the development of an antiviral state. ISG15 is a versatile molecule directly modulating both host and virus protein function which regulate many signaling pathways, including its own synthesis. Here we review the various roles ISG15 plays in the antiviral immune response, and examine the mechanisms by which viruses attempt to mitigate or exploit ISG15 activity.

中文翻译：

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ISG15 如何对抗病毒感染。

干扰素 (IFN) 刺激的基因产物 15 (ISG15) 是一种泛素样蛋白质，对控制微生物感染至关重要。ISG15 似乎具有多种功能，可调节多种细胞反应，促进抗病毒状态的发展。ISG15 是一种多功能分子，可直接调节宿主和病毒蛋白质功能，可调节许多信号通路，包括其自身的合成。在这里，我们回顾了 ISG15 在抗病毒免疫反应中的各种作用，并检查病毒试图减轻或利用 ISG15 活动的机制。