Abstract Tailoring surface hydrophilicity on polyethylene terephthalate (PET) by a radio frequency (RF) atmospheric pressure plasma jet (APPJ) for grafting biomaterials was investigated in this study. Two thermally responsive biomaterials of hydrophilic non-ionic surfactant of polyoxyethylene polymer and hydroxypropyl cellulose were used, while hydroxyethylmethacrylate (HEMA) was applied as the carrier for drug release. As applying the RF power in an APPJ system, PET substrates represented a tendency from an originally hydrophobic surface to a hydrophilic one, while apparent damaged areas were observed as the RF power exceeded 200 W. APPJ-induced polar functional groups onto PET surface without serious etching were most likely to improve the surface hydrophilicity for further grafting biomaterials. The grafted polyoxyethylene polymer on APPJ-treated PET substrates exhibited a surface change from opaque into transparent as the ambient temperature exceeded lower critical solution temperature of 37°C, while hydroxypropyl cellulose displayed a change from transparent into milky white as the temperature over 55°C. For the drug release behavior of aspirin on APPJ-treated PET substrates, the cumulative release rate of aspirin entrapped substrate for 3 h was 22%. Our results suggest that tailoring surface hydrophilicity of PET substrates without surface etching by 100W-APPJ process possessed a higher surface energy with a higher polar interaction, resulting in a good bonding with the grafted biomaterials.

中文翻译：

---

用常压等离子体射流调整聚对苯二甲酸乙二醇酯的表面特性以接枝生物材料

摘要 本研究研究了通过射频 (RF) 大气压等离子体射流 (APPJ) 调整聚对苯二甲酸乙二醇酯 (PET) 的表面亲水性以接枝生物材料。采用聚氧乙烯聚合物亲水性非离子表面活性剂和羟丙基纤维素两种热响应性生物材料，以甲基丙烯酸羟乙酯(HEMA)为载体进行药物释放。在 APPJ 系统中应用 RF 功率时，PET 基材表现出从最初疏水表面到亲水表面的趋势，而当 RF 功率超过 200 W 时观察到明显的损坏区域。 APPJ 诱导的极性官能团在 PET 表面上没有严重蚀刻最有可能提高表面亲水性以进一步接枝生物材料。当环境温度超过下临界溶解温度 37°C 时，在 APPJ 处理的 PET 基材上接枝的聚氧乙烯聚合物表现出从不透明到透明的表面变化，而当温度超过 55°C 时，羟丙基纤维素表现出从透明到乳白色的变化. 对于阿司匹林在 APPJ 处理的 PET 基材上的药物释放行为，阿司匹林包裹的基材 3 小时的累积释放率为 22%。我们的结果表明，通过 100W-APPJ 工艺在没有表面蚀刻的情况下定制 PET 基材的表面亲水性具有更高的表面能和更高的极性相互作用，从而与接枝生物材料形成良好的结合。