Crisponi syndrome/cold-induced sweating syndrome type 2 (CS/CISS2) is a rare disease with severe dysfunctions of thermoregulatory processes. CS/CISS2 individuals suffer from recurrent episodes of hyperthermia in the neonatal period and paradoxical sweating at cold ambient temperatures in adolescence. Variants in CLCF1 (cardiotrophin-like-cytokine 1) cause CS/CISS2. Here, we summarize the generation of three clones of one stem cell line (iPSC) of a CS/CISS2 individual carrying the CLCF1 variant c.321C>G on both alleles. These patient derived iPSC clones show a normal karyotype, several pluripotency markers, and the ability to differentiate into the three germ layers.

Crisponi综合征/ 2型冷汗综合征（CS / CISS2）是一种罕见的疾病，具有严重的体温调节功能障碍。CS / CISS2个体在新生儿时期反复发作高热，并在青春期寒冷的环境温度下出现反常的出汗。变体在CLCF1（心肌营养素样细胞因子1）引起CS / CISS2。在这里，我们总结了在两个等位基因上均携带CLCF1变体c.321C> G的CS / CISS2个体的一个干细胞系（iPSC）的三个克隆的生成。这些患者来源的iPSC克隆显示出正常的核型，几种多能性标记以及分化为三个胚层的能力。