Cell death plays a critical role in organism development and the pathogenesis of diseases. Necrosis is considered a non-programmed cell death in an extreme environment. Recent advances have provided solid evidence that necrosis could be programmed and quite a few types of programmed necrosis, such as necroptosis, ferroptosis, pyroptosis, paraptosis, mitochondrial permeability transition-driven necrosis, and oncosis, have been identified. The specific biomarkers, detailed signaling, and precise pathophysiological importance of programmed necrosis are yet to be clarified, but these forms of necrosis provide novel strategies for the treatment of various diseases, including cancer. Natural compounds are a unique source of lead compounds for the discovery of anti-cancer drugs. Natural compounds can induce both apoptosis and programmed necrosis. In this review, we summarized the recent progress of programmed necrosis and introduced their natural inducers. Noptosis, which is a novel type of programmed necrosis that is strictly dependent on NAD(P)H: quinone oxidoreductase 1-derived oxidative stress was proposed. Furthermore, the anti-cancer strategies that take advantage of programmed necrosis and the main concerns from the scientific community in this regard were discussed.

细胞死亡在生物发展和疾病的发病机理中起着至关重要的作用。坏死被认为是在极端环境下的非程序性细胞死亡。最近的进展提供了可靠的证据，表明可以对坏死进行程序化，并且已经确定了许多类型的程序性坏死，例如坏死性坏死病，ferroptosis，烧伤，截瘫，线粒体通透性转变驱动的坏死和肿瘤。程序性坏死的具体生物标志物，详细的信号传导和精确的病理生理重要性尚未阐明，但是这些坏死形式为治疗包括癌症在内的各种疾病提供了新的策略。天然化合物是发现抗癌药物的先导化合物的独特来源。天然化合物可诱导凋亡和程序性坏死。在这篇综述中，我们总结了程序性坏死的最新进展，并介绍了其自然诱导物。提出了Noptosis，这是一种严格依赖于NAD（P）H的新型程序性坏死：醌氧化还原酶1衍生的氧化应激。此外，还讨论了利用程序性坏死的抗癌策略以及科学界在这方面的主要关注。