Abstract (HL) ligand is synthesized by treatment of ethene 1,2-diamine, 2-hydroxybenzaldehyde and furan-2- carbaldehyde in 1: 1:1 ratio. Co2+, Mn2+, Ni2+ and Zn2+ chelates have been designed and obtained. Thermal analysis, elemental analyses, conductivity and spectral measurements are factors but they are measurements or tools. The metal complexes were predicted to be not electrolytic due to their measured values of molar conductance. The arranged octahedral geometries of M(II) (Mn, Co, Ni and Zn) complexes are determined via magnetic moment and UV–Vis spectral data. Metal chelates’ decomposition kinetics and thermal properties are observed using Coats-Redfern method. Entropy of activation (ΔS), activation energy (E) and pre-exponential factor (A), which are the kinetic parameters, were quantified. Molecular modeling assisted the optimization of metal complexes’ geometry. Interaction of metal chelates with calf thymus DNA (CT-DNA) was evaluated via UV–Vis absorption and viscosity measurements. The obtained data elucidated that the complexes interact with DNA by partial or non-intercalative binding mode for these compounds. Also, the target compounds were tested for their in-vitro antimicrobial and anticancer efficacy.

中文翻译：

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1,2-乙二胺席夫碱配体二价金属(II)螯合物的合成、结构鉴定、DNA相互作用和生物学研究

摘要 (HL) 配体是由乙烯 1,2-二胺、2-羟基苯甲醛和呋喃-2-甲醛按 1:1:1 的比例处理合成的。已经设计并获得了 Co2+、Mn2+、Ni2+ 和 Zn2+ 螯合物。热分析、元素分析、电导率和光谱测量是因素，但它们是测量或工具。由于其摩尔电导的测量值，预测金属配合物不是电解的。M(II)（Mn、Co、Ni 和 Zn）配合物的排列八面体几何形状是通过磁矩和 UV-Vis 光谱数据确定的。使用 Coats-Redfern 方法观察金属螯合物的分解动力学和热性能。对作为动力学参数的活化熵 (ΔS)、活化能 (E) 和指前因子 (A) 进行量化。分子建模有助于优化金属配合物的几何形状。通过 UV-Vis 吸收和粘度测量评估金属螯合物与小牛胸腺 DNA (CT-DNA) 的相互作用。获得的数据阐明了复合物通过这些化合物的部分或非嵌入结合模式与 DNA 相互作用。此外，还测试了目标化合物的体外抗微生物和抗癌功效。