Abstract Illegal use of nitrofurans (NFs) in aquaculture is of great concern for food safety throughout the world. A liquid chromatography-based method coupled to tandem mass spectrometry was developed and validated for measuring levels of four conventional NFs (nitrofurantoin, furazolidone, nitrofurazone, and furaltadone) and four additional NFs (nifursol, nifuroxazide, nifurpirinol, and sodium nifurstyrenate) in shellfish and fish samples. Limits of detection and quantitation were 0.01–0.2 µg/kg and 0.04–0.5 µg/kg for seven NFs, except for sodium nifurstyrenate (2 µg/kg and 5 µg/kg). Recoveries were 91.6–107.3 % with inter-day and intra-day relative standard deviations in the range of 0.8–9.6 % and 0.7–10.7 %, which were assessed at four fortification levels. The validated method was applied to 397 shellfish and 140 fish collected from South China in 2014−2017. The total non-compliant rate (>1.0 µg/kg) of the four major NFs was 4.3 % in shellfish (

中文翻译：

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超高效液相色谱-串联质谱法同时测定贝类和鱼类中八种硝基呋喃残留

摘要 水产养殖中硝基呋喃（NFs）的非法使用是全世界食品安全的重大问题。开发并验证了一种基于液相色谱与串联质谱联用的方法，可用于测量贝类和贝类中四种常规 NF（呋喃妥因、呋喃唑酮、硝基呋喃酮和呋拉他酮）和四种其他 NF（硝呋索、硝呋齐特、硝呋匹林和硝基苯磺酸钠）的水平。鱼样品。七种 NF 的检测限和定量限为 0.01–0.2 µg/kg 和 0.04–0.5 µg/kg，硝呋苯乙烯酸钠（2 µg/kg 和 5 µg/kg）除外。回收率为 91.6-107.3%，日间和日内相对标准偏差在 0.8-9.6% 和 0.7-10.7% 的范围内，在四个设防级别进行评估。经验证的方法应用于2014-2017年从华南采集的397种贝类和140种鱼类。贝类中四种主要 NF 的总不合规率 (>1.0 µg/kg) 为 4.3% (