Temporal lobe epilepsy leads to a disturbance in the function and dynamic of the mitochondria. The mitoKATP channel is an important factor in controlling mitochondrial function. In this study, the protective role of mitoKATP was studied in temporal lobe epilepsy through the regulation of mitochondrial dynamic proteins. After induction of epilepsy, 5-HD (the inhibitor of mitoKATP) was administered daily for either 24 or 72 h. The results revealed an imbalance in dynamic proteins after epilepsy, specifically in the first 72 h. The disturbance in the mitochondrial dynamic worsened after blocking mitoKATP. In conclusion, mitoKATP has an important role in balancing mitochondrial dynamic proteins in epilepsy.

中文翻译：

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线粒体 ATP 敏感钾通道 MitoKATP 改善颞叶癫痫引起的线粒体动态紊乱

颞叶癫痫会导致线粒体功能和动态紊乱。mitoKATP 通道是控制线粒体功能的重要因素。本研究通过线粒体动态蛋白的调控研究了mitoKATP在颞叶癫痫中的保护作用。诱发癫痫后，每天服用 5-HD（mitoKATP 抑制剂）24 或 72 小时。结果显示癫痫后动态蛋白不平衡，特别是在前 72 小时内。阻断 mitoKATP 后，线粒体动态紊乱恶化。总之，mitoKATP 在平衡癫痫中的线粒体动态蛋白方面具有重要作用。