Objective

Cancer-related inflammation (CRI) is thought to be a successful predictor of prognosis in colon cancers (CC), but opinions on how to use it are highly variable. In this study, the role of CRI cells in survival for CC patients was investigated by considering gender and menopausal status.

Methods

163 stage II/III CC patients who underwent curative surgery between 1995 and 2015 were included in the study. The relationship between CRI cells was examined using a standard methodology.

Results

High neutrophil-lymphocyte ratio (NLR) had a better relationship with prognostic factors, especially in postmenopausal women (gender, p = 0.037, positive surgical margin, p = 0.001; MSI, p < 0.001; Crohn’s-like reaction, p = 0.001, etc). Also, the reproducibility of the study was better in postmenopausal women (intra-observer agreement = 0.72, intra-class correlation = 0.722, correlation of estimates = 0.718). In univariate analysis, 5-year survival was worse in postmenopausal women with high NLR (OS, p = 0.001; RFS, p < 0.001). In multivariate analysis, high NLR was independently a worse biomarker for OS (hazard ratio [HR], 1.29; 95% CI, 1.18–2.12; p = 0.001) and RFS (HR, 1.30; 95% CI, 1.21–2.59; p < 0.001) in postmenopausal women.

Conclusions

NLR had an independent poor prognostic significance in postmenopausal female patients, and the use of a standard approach for methodology improved successful results.

中文翻译：

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癌症相关炎症在绝经后女性II / III期结肠癌患者预后不良中的作用。

目的

癌症相关的炎症（CRI）被认为是结肠癌（CC）预后的成功预测指标，但是有关如何使用它的意见却存在很大差异。在这项研究中，通过考虑性别和更年期状态来研究CRI细胞在CC患者生存中的作用。

方法

该研究纳入了1995年至2015年间接受根治性手术的163名II / III期CC患者。使用标准方法检查了CRI细胞之间的关系。

结果

中性粒细胞-淋巴细胞比率（NLR）高与预后因素有更好的关系，尤其是在绝经后妇女中（性别，p = 0.037，手术切缘阳性，p = 0.001； MSI，p <0.001；克罗恩氏样反应，p = 0.001，等等）。而且，该研究的可重复性在绝经后妇女中更好（观察者内部一致度= 0.72，组内相关度= 0.722，估计相关度= 0.718）。在单因素分析中，绝经后女性中具有较高NLR的5年生存率较差（OS，p = 0.001； RFS，p <0.001）。在多变量分析中，高NLR分别是OS（危险比[HR]为1.29； 95％CI为1.18-2.12； p = 0.001）和RFS（HR为1.30； 95％CI为1.21-2.59； p <0.001）。

结论

NLR在绝经后的女性患者中具有独立的不良预后意义，采用标准方法进行方法可提高成功率。