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Prussian blue nanoparticles: synthesis, surface modification, and biomedical applications.
Drug Discovery Today ( IF 6.5 ) Pub Date : 2020-05-31 , DOI: 10.1016/j.drudis.2020.05.014
Maria Antònia Busquets 1 , Joan Estelrich 1
Affiliation  

Prussian blue nanoparticles (PBNPs) are a nanomaterial that presents unique properties and an excellent biocompatibility. They can be synthesized in mild conditions and can be derivatized with polymers and/or biomolecules. PBNPs are used in biomedicine as therapy and diagnostic agents. In biomedical imaging, PBNPs constitute contrast agents in photoacoustic and magnetic resonance imaging (MRI). They are a good adsorbent to be used as antidotes for poisoning with cesium and/or thallium ions. Moreover, the ability to convert energy into heat makes them useful photothermal agents (PAs) in photothermal therapy (PTT) or as nonantibiotic substances with antibacterial properties. Finally, PBNPs can be both reduced to Prussian white and oxidized to Prussian green. A large window of redox potential exists between reduction and oxidation, which result in the enzyme-like characteristics of these NPs.



中文翻译:

普鲁士蓝纳米粒子:合成、表面改性和生物医学应用。

普鲁士蓝纳米粒子 (PBNPs) 是一种纳米材料,具有独特的特性和出色的生物相容性。它们可以在温和的条件下合成,并且可以用聚合物和/或生物分子衍生化。PBNP 在生物医学中用作治疗和诊断剂。在生物医学成像中,PBNP 构成光声和磁共振成像 (MRI) 中的造影剂。它们是一种很好的吸附剂,可用作铯和/或铊离子中毒的解毒剂。此外,将能量转化为热量的能力使它们成为光热疗法 (PTT) 中有用的光热剂 (PA) 或作为具有抗菌特性的非抗生素物质。最后,PBNPs 既可以还原为普鲁士白,也可以氧化为普鲁士绿。还原和氧化之间存在很大的氧化还原电位窗口,

更新日期:2020-05-31
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