Catalyst-controlled site selectivity in C−H functionalization reactions is a long-standing challenge. In this issue of Chem, Larrosa and co-workers employ a cyclometalated ruthenium catalyst (RuBnN) to reverse the conventional meta-selectivity to the unprecedented ortho-selectivity in the C(sp²)−H alkylation of arenes with secondary alkyl halides.

中文翻译：

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通过环金属化钌催化剂从间位选择性转变为邻位选择性

在CH官能化反应中催化剂控制的位点选择性是一个长期的挑战。在本期《化学》杂志上，Larrosa及其同事采用了一种环金属化钌催化剂（RuBnN），将芳烃的C（sp ²）-H烷基化与仲烷基卤化物的常规间位选择性逆转为前所未有的邻位选择性。