OBJECTIVE To assess the phenotypic characteristics of patients with Chronic Obstructive Pulmonary Disease (COPD) after stratification for Short Physical Performance Battery (SPPB) summary scores and to determine phenotypic characteristics of the SPPB summary score at the start of pulmonary rehabilitation (PR). DESIGN Retrospective, cross-sectional. SETTING Baseline assessment for PR program. PARTICIPANTS 900 patients with COPD (age 65±8 years, 52% male, FEV1 43 (31-62)% predicted). INTERVENTIONS Not applicable. MAIN OUTCOME MEASURE Patients were stratified according to their SPPB summary scores into low-performance (LP), moderate-performance (MP) or high-performance (HP). Furthermore, lung function, arterial blood gases, body composition, physical capacity, lower-limb muscle strength and endurance and symptoms of anxiety and depression were assessed. RESULTS Generally, physical capacity and muscle function were lower and scores for symptoms of anxiety and depression were higher in LP patients compared to MP and HP patients (all values, p<0.01). However, 25% of HP patients with COPD scored high on symptoms of anxiety and/or depression (≥10 points) and HP patients still had on average an impaired physical capacity (median 6 minute walk test distance (6MWD) distance of 68% predicted). Furthermore, age and 6MWD (meters) were the only independent predictors in a multivariate regression model, explaining 29% of the variance in SPPB summary score. CONCLUSIONS In COPD, LP patients have the worst physical and emotional functioning. However, HP patients can still exhibit physical and emotional impairments. As the explained variance in SPPB summary score is low, SPPB should not be considered as a test to discriminate between patients with COPD with a low or preserved physical capacity and emotional status.

中文翻译：

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慢性阻塞性肺疾病患者的表型特征在对短期身体表现电池总结评分进行分层后。

目的 评估慢性阻塞性肺疾病 (COPD) 患者在短期体能电池 (SPPB) 总分分层后的表型特征，并确定 SPPB 总分在肺康复 (PR) 开始时的表型特征。设计 回顾性、横断面。设定 PR 计划的基线评估。参与者 900 名 COPD 患者（年龄 65±8 岁，52% 男性，FEV1 43 (31-62)% 预测值）。干预 不适用。主要结果测量 根据患者的 SPPB 总分将患者分为低绩效 (LP)、中等绩效 (MP) 或高性能 (HP)。此外，肺功能、动脉血气、身体成分、体能、评估了下肢肌肉力量和耐力以及焦虑和抑郁症状。结果 通常，与 MP 和 HP 患者相比，LP 患者的体能和肌肉功能较低，焦虑和抑郁症状的评分较高（所有值，p < 0.01）。然而，25% 的患有 COPD 的 HP 患者在焦虑和/或抑郁症状上得分较高（≥10 分），并且 HP 患者的平均身体能力仍然受损（中位 6 分钟步行测试距离 (6MWD) 距离为预测的 68%） ）。此外，年龄和 6MWD（米）是多元回归模型中唯一的独立预测因子，解释了 SPPB 总分中 29% 的方差。结论 在 COPD 中，LP 患者的身体和情绪功能最差。然而，HP 患者仍可能表现出身体和情绪障碍。