The aim of the present study was to analyze IL6 rs1800795 genetic variant in the susceptibility to Trypanosoma cruzi infection and in the development of chronic Chagas cardiomyopathy (CCC), in five independent Latin American cohorts. A total of 3,087 individuals from Latin American countries (Argentina, Bolivia, Peru, and two cohorts from Colombia) were studied. In all cohorts, patients were classified as seropositive for T. cruzi antigens (n= 1,963) and seronegative (n= 1,124). Based on clinical evaluation, the seropositive patients, were classified as CCC (n= 900) and asymptomatic (n= 1,063). No statistically significant differences in the frequency of IL6 rs1800795 between seropositive and seronegative, or between CCC and asymptomatic patients, were found. Furthermore, after the meta-analysis no statistically significant differences were observed. Our results do not support a contribution of IL6 rs1800795 genetic variant in the susceptibility to the infection and the development of chronic Chagas cardiomyopathy in the studied populations.

本研究的目的是在五个独立的拉丁美洲队列中分析IL6 rs1800795遗传变异对克鲁斯锥虫感染的敏感性以及慢性恰加斯氏心肌病（CCC）的发展。研究了来自拉丁美洲国家（阿根廷，玻利维亚，秘鲁和哥伦比亚的两个队列）的3,087个人。在所有队列中，患者被分类为克氏锥虫血清阳性（n = 1,963）和血清阴性（n = 1,124）。根据临床评估，血清反应阳性的患者分为CCC（n = 900）和无症状（n = 1,063）。IL6频率无统计学差异在血清反应阳性和血清阴性之间，或在CCC和无症状患者之间发现rs1800795。此外，荟萃分析后未观察到统计学上的显着差异。我们的结果不支持IL6 rs1800795基因变异在研究人群中对慢性Chagas心肌病的感染易感性和发展的贡献。