DEHP (Di-ethyl hexyl phthalate), an ubiquitous chemical constituent of plasticizer, cosmetics etc. poses different abnormal neurological and behavioral responses in eukaryotic model organism C. elegans (Caenorhabditis elegans). Based upon such reports, we hypothesized that due to exposure of DEHP, the larval growth of C. elegans was altered and animals went into dauer at high concentrations of exposure at 8.26 ppm. Using chemosensory assay, the orientation of repulsion (− 0.1) of the nematodes were determined with exposure of DEHP at 4.78 ppm and 8.26 ppm. We show that N2 wild type worms display a preferential food choice and search for favorable food, and alter two modes of locomotion (forward and backward) that measures the maximum bending rate of an adult worm. Thermo sensation also plays a crucial role in determining the toxicity level in C. elegans at 15 °C, 20 °C, and 25 °C. Understanding the chemosensory pattern towards a specific chemical for C. elegans, the recent work could shed light in exploring the molecular mechanism involved in the tactile movement of the worms against a specific chemical, thereby making worms a potential biological sensing platform for external stimuli perception.

增塑剂，化妆品等普遍存在的化学成分DEHP（邻苯二甲酸二乙基己酯）在真核模型生物秀丽隐杆线虫（秀丽隐杆线虫）中引起不同的异常神经和行为反应。根据这些报告，我们假设由于暴露于DEHP，秀丽隐杆线虫的幼虫生长改变了动物的状态，高浓度暴露于8.26 ppm时动物进入了dauer。使用化学感测法，通过在4.78 ppm和8.26 ppm的DEHP暴露下确定线虫的排斥方向（-0.1）。我们显示，N2野生型蠕虫显示出优先的食物选择并寻找有利的食物，并且改变了测量成虫最大弯曲率的两种运动方式（前进和后退）。热感觉在确定C的毒性水平中也起着至关重要的作用。线虫在15°C，20°C和25°C的温度下。了解针对秀丽线虫的特定化学物的化学感应模式， 最近的工作可能会为探索蠕虫针对特定化学物质的触觉运动所涉及的分子机制提供启发，从而使蠕虫成为潜在的外部刺激感知生物传感平台。