The solution of the inverse problem of electrocardiology allows the reconstruction of the spatial distribution of the electrical activity of the heart from the body surface electrocardiogram (electrocardiographic imaging, ECGI). ECGI using the equivalent dipole layer (EDL) model has shown to be accurate for cardiac activation times. However, validation of this method to determine repolarization times is lacking. In the present study, we determined the accuracy of the EDL model in reconstructing cardiac repolarization times, and assessed the robustness of the method under less ideal conditions (addition of noise and errors in tissue conductivity). A monodomain model was used to determine the transmembrane potentials in three different excitation-repolarization patterns (sinus beat and ventricular ectopic beats) as the gold standard. These were used to calculate the body surface ECGs using a finite element model. The resulting body surface electrograms (ECGs) were used as input for the EDL-based inverse reconstruction of repolarization times. The reconstructed repolarization times correlated well (COR > 0.85) with the gold standard, with almost no decrease in correlation after adding errors in tissue conductivity of the model or noise to the body surface ECG. Therefore, ECGI using the EDL model allows adequate reconstruction of cardiac repolarization times.

Validation of electrocardiographic imaging for repolarization using forward calculated body surface ECGs from simulated activation-repolarization sequences.

心电学逆问题的解决方案允许从体表心电图（心电图成像，ECGI）重建心脏电活动的空间分布。使用等效偶极子层（EDL）模型的ECGI已证明对于心脏激活时间是准确的。但是，缺乏对该方法确定复极化时间的验证。在本研究中，我们确定了EDL模型在重建心脏复极过程中的准确性。次，并在不太理想的条件下（噪声和组织电导率误差）评估了该方法的鲁棒性。使用单畴模型确定三种不同的激发-复极化模式（窦性搏动和心室异位搏动）的跨膜电位作为金标准。这些被用于使用有限元模型来计算体表心电图。所得的体表电描记图（ECG）用作基于EDL的反极化时间反向重构的输入。重建的复极时间与金标准相关性很好（COR> 0.85），在增加了模型的组织电导率误差或对体表ECG的噪声后，相关性几乎没有降低。因此，使用EDL模型的ECGI可以充分重建心脏复极时间。

使用从模拟的激活-重新极化序列中预先计算的体表心电图，对重新极化的心电图成像进行验证。