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Differential Expression of Bipotent Commitment-Related Genes in Multipotent Mesenchymal Stromal Cells at Different O2 Levels.
Doklady Biochemistry and Biophysics ( IF 0.8 ) Pub Date : 2020-06-01 , DOI: 10.1134/s1607672920020052 L B Buravkova 1 , M I Ezdakova 1 , I V Andrianova 1 , E A Golikova 1 , E R Andreeva 1
中文翻译:
双能承诺相关基因在不同O2水平下在多能间质基质细胞中的差异表达。
更新日期:2020-06-01
Doklady Biochemistry and Biophysics ( IF 0.8 ) Pub Date : 2020-06-01 , DOI: 10.1134/s1607672920020052 L B Buravkova 1 , M I Ezdakova 1 , I V Andrianova 1 , E A Golikova 1 , E R Andreeva 1
Affiliation
Abstract
The transcriptomic profile associated with osteo- and adipogenic differentiation in growth-arrested multipotent mesenchymal stromal cells (MSCs) from human adipose tissue was analyzed in vitro at 20% (standard laboratory) and 5% (tissue-related) O2 levels. Compared with day 7, at 5% O2 on day 14 spontaneous upregulation of osteo- (RUNX2, SP7, BGLAP, and SPP1) and adipogenic differentiation (CEBPA, PPARG, and ADIPOQ) genes in MSCs was observed (p < 0.05). Thus, upon expansion under tissue-related O2, MSCs demonstrated a bipotent transcriptomic profile, which may contribute to the improvement of their hematopoiesis-supportive function.中文翻译:
双能承诺相关基因在不同O2水平下在多能间质基质细胞中的差异表达。