Invasive Lactococcus lactis producing mycobacterial Hsp65 ameliorates intestinal inflammation in acute TNBS-induced colitis in mice by increasing the levels of the cytokine IL-10 and secretory IgA.,Journal of Applied Microbiology

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Invasive Lactococcus lactis producing mycobacterial Hsp65 ameliorates intestinal inflammation in acute TNBS-induced colitis in mice by increasing the levels of the cytokine IL-10 and secretory IgA.
Journal of Applied Microbiology ( IF 3.2 ) Pub Date : 2020-05-30 , DOI: 10.1111/jam.14695
V P da Cunha ₁ , T M Preisser ₁ , M P Santana ₁ , D C C Machado ₂ , V B Pereira ₁ , A Miyoshi ₁

Affiliation

To investigate the anti‐inflammatory activity of an invasive and Hp65‐producing strain Lactococcus lactis NCDO2118 FnBPA+ (pXYCYT:Hsp65) in acute 2,4,6‐trinitrobenzene sulphonic acid (TNBS)‐induced colitis in mice as an innovative therapeutic strategy against Crohn's disease (CD).

中文翻译：

通过增加细胞因子IL-10和分泌型IgA的水平，产生乳酸杆菌球菌的Hsp65分枝杆菌可改善小鼠急性TNBS诱发的结肠炎的肠道炎症。

研究侵袭性和产生Hp65的乳酸乳球菌NCDO2118 FnBPA +（pXYCYT：Hsp65）在急性2,4,6-三硝基苯磺酸（TNBS）诱发的小鼠结肠炎中的抗炎活性，作为针对克罗恩氏病的创新治疗策略疾病（CD）。

更新日期：2020-05-30

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