Although combination antiretroviral therapy (cART) has simplified over the past decade, polypharmacy is increasing for older people living with HIV (PLWH) due to the emergence of multiple health comorbidities. This study examined predictors of, and relationships between, objective (Medication Management Test-Revised (MMT-R)) and self-reported medication management ability in older (≥ 50 years) PLWH (n = 146) compared with HIV-uninfected (HIV-) individuals (n = 60). PLWH scored worse on the MMT-R and had a higher pill burden compared with HIV- individuals. MMT-R failure was predicted by HIV status, race, reading level, and worse executive functioning, as well as history of Hepatitis C and detectable viral load in PLWH. Self-reported ability to manage medications did not relate to MMT-R score. Older PLWH may not self-describe concerns regarding their ability to manage complex medication regimens. Our results emphasize the need for objective measurements of medication management ability.

中文翻译：

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与健康的老年艾滋病毒对照者相比，老年艾滋病毒感染者的药物管理能力有所下降。


尽管联合抗逆转录病毒疗法 (cART) 在过去十年中已得到简化，但由于多种健康合并​​症的出现，针对老年艾滋病毒感染者 (PLWH) 的多重用药正在增加。本研究考察了老年（≥ 50 岁）PLWH（n = 146）与未感染 HIV 的患者（HIV -) 个人 (n = 60)。与 HIV 感染者相比，PLWH 在 MMT-R 上的得分较低，并且药物负担较高。 MMT-R 失败是通过 HIV 状况、种族、阅读水平和较差的执行功能以及丙型肝炎病史和 PLWH 中可检测到的病毒载量来预测的。自我报告的药物管理能力与 MMT-R 评分无关。老年感染者可能不会自我描述对其管理复杂药物治疗方案能力的担忧。我们的结果强调需要客观衡量药物管理能力。