The Adenovirus Death Protein – A small membrane protein controls cell lysis and disease,FEBS Letters

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The Adenovirus Death Protein – A small membrane protein controls cell lysis and disease
FEBS Letters ( IF 3.0 ) Pub Date : 2020-06-01 , DOI: 10.1002/1873-3468.13848
Fanny Georgi ₁ , Urs F Greber ₁

Affiliation

Human adenoviruses (HAdVs) cause widespread acute and persistent infections. Infections are usually mild and controlled by humoral and cell‐based immunity. Reactivation of persistently infected immune cells can lead to a life‐threatening disease in immunocompromised individuals, especially children and transplant recipients. To date, no effective therapy or vaccine against HAdV disease is available to the public. HAdV‐C2 and C5 are the best‐studied of more than 100 HAdV types. They persist in infected cells and release their progeny by host cell lysis to neighbouring cells and fluids, a process facilitated by the adenovirus death protein (ADP). ADP consists of about 100 amino acids and harbours a single membrane‐spanning domain. It undergoes post‐translational processing in endoplasmic reticulum and Golgi compartments, before localizing to the inner nuclear membrane. Here, we discuss the current knowledge on how ADP induces membrane rupture. Membrane rupture is essential for both progression of disease and efficacy of therapeutic viruses in clinical applications, in particular oncolytic therapy.

中文翻译：

腺病毒死亡蛋白——一种控制细胞裂解和疾病的小膜蛋白

人类腺病毒 (HAdV) 会引起广泛的急性和持续性感染。感染通常是轻微的，由体液和细胞免疫控制。持续感染的免疫细胞的重新激活可导致免疫功能低下的个体，尤其是儿童和移植受者发生危及生命的疾病。迄今为止，还没有针对 HAdV 疾病的有效疗法或疫苗可供公众使用。HAdV-C2 和 C5 是 100 多种 HAdV 类型中研究得最好的。它们在受感染的细胞中持续存在并通过宿主细胞裂解释放其后代到邻近的细胞和体液中，这一过程由腺病毒死亡蛋白 (ADP) 促进。ADP 由大约 100 个氨基酸组成，并具有单个跨膜结构域。它在内质网和高尔基体区室中进行翻译后加工，在定位到内核膜之前。在这里，我们讨论有关 ADP 如何诱导膜破裂的当前知识。膜破裂对于疾病的进展和治疗性病毒在临床应用中的功效都是必不可少的，尤其是溶瘤治疗。

更新日期：2020-06-01

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