The importance of genomic information in intrinsic brain tumors is highlighted in the World Health Organization (WHO) 2016 classification of gliomas, which now incorporates both phenotype and genotype data to assign a diagnosis. By using genetic markers to both categorize tumors and advise patients on prognosis, this classification system has minimized the risk of tissue sampling error, improved diagnostic accuracy, and reduced inter-rater variability. In the neurosurgical community, it is critical to understand the role genetics plays in tumor biology, what certain mutations mean for the patient's prognosis and adjuvant treatment, and how to interpret the results of sequencing data that are generated following tumor resection. In this review, we examine the critical role of genetics for diagnosis and prognosis and highlight the importance of tumor genetics for neurosurgeons caring for patients with diffuse lower grade gliomas.

中文翻译：

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弥散性低度神经胶质瘤的分子特征：神经外科医生需要知道的内容。

世界卫生组织（WHO）2016年对神经胶质瘤的分类中强调了基因组信息在固有脑肿瘤中的重要性，该分类现在结合了表型和基因型数据以进行诊断。通过使用遗传标记对肿瘤进行分类并为患者提供预后建议，该分类系统将组织采样错误的风险降至最低，提高了诊断准确性，并降低了评分者间的差异。在神经外科领域，了解遗传学在肿瘤生物学中的作用，某些突变对患者的预后和辅助治疗意味着什么以及如何解释肿瘤切除后产生的测序数据的结果至关重要。在这篇评论中