Studying biological characteristics of tumors and evaluating the treatment effects require appropriate in vitro tumor models. However, the occurrence, progression, and migration of tumors involve spatiotemporal changes, cell–microenvironment and cell–cell interactions, and signal transmission in cells, which makes the construction of in vitro tumor models extremely challenging. In the past few years, advances in biomaterials and tissue engineering methods, especially development of the bioprinting technology, have paved the way for innovative platform technologies for in vitro cancer research. Bioprinting can accurately control the distribution of cells, active molecules, and biomaterials. Furthermore, this technology recapitulates the key characteristics of the tumor microenvironment and constructs in vitro tumor models with bionic structures and physiological systems. These models can be used as robust platforms to study tumor initiation, interactio...

中文翻译：

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用于个性化癌症治疗的体外肿瘤模型的生物打印：综述。

研究肿瘤的生物学特性并评估治疗效果需要适当的体外肿瘤模型。但是，肿瘤的发生，发展和迁移涉及时空变化，细胞微环境和细胞间相互作用以及细胞中的信号传递，这使得体外肿瘤模型的构建极具挑战性。在过去的几年中，生物材料和组织工程方法的进步，尤其是生物打印技术的发展，为体外癌症研究的创新平台技术铺平了道路。生物打印可以准确地控制细胞，活性分子和生物材料的分布。此外，该技术概述了肿瘤微环境的关键特征，并构建了具有仿生结构和生理系统的体外肿瘤模型。这些模型可以用作研究肿瘤发生，相互作用和治疗的可靠平台。