Introduction: Quinoxalines show diversified applications in the field of medicinal chemistry.

Materials and Methods: Therefore, we have designed a highly efficient, environmentally benign and one-pot protocol for the synthesis of 2-phenylquinoxaline from the reaction of Acetophenone, N-bromosuccinimide and 1,2-phenylenediamine under ultrasound irradiation in glycerol-water.

Results and Discussion: We observed that, although the reaction efficiently completed in all of these solvents, the use of glycerol-water with different ratios gives consistently higher yields (89–94%) and decreases reaction times.

Conclusion: The main advantages of this protocol are that it is a green method, avoids the use of toxic catalysts and volatile organic medium and the product is obtained with excellent yield.

简介：喹喔啉在药物化学领域显示出多种应用。

材料和方法：因此，我们设计了一种高效，环境友好的一锅法实验方案，用于在甘油-水中超声照射下苯乙酮，N-溴琥珀酰亚胺和1,2-苯二胺的反应合成2-苯基喹喔啉。

结果与讨论：我们观察到，尽管在所有这些溶剂中都能有效地完成反应，但使用不同比例的甘油-水可始终如一地提高产率（89-94％）并缩短反应时间。

结论：该方案的主要优点是它是一种绿色方法，避免使用有毒催化剂和挥发性有机介质，且收率高。