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Highly efficient ultrasound promoted synthesis of 2-phenylquinoxaline in glycerol-water.
Current Organic Synthesis ( IF 1.7 ) Pub Date : 2020-08-31 , DOI: 10.2174/1570179417666200529121602
Mujahed Shaikh 1 , Devendra Wagare 2 , Ashvini Sonone 1 , Ayesha Durrani 1
Affiliation  

Introduction: Quinoxalines show diversified applications in the field of medicinal chemistry.

Materials and Methods: Therefore, we have designed a highly efficient, environmentally benign and one-pot protocol for the synthesis of 2-phenylquinoxaline from the reaction of Acetophenone, N-bromosuccinimide and 1,2-phenylenediamine under ultrasound irradiation in glycerol-water.

Results and Discussion: We observed that, although the reaction efficiently completed in all of these solvents, the use of glycerol-water with different ratios gives consistently higher yields (89–94%) and decreases reaction times.

Conclusion: The main advantages of this protocol are that it is a green method, avoids the use of toxic catalysts and volatile organic medium and the product is obtained with excellent yield.



中文翻译:

高效超声促进了甘油-水中2-苯基喹喔啉的合成。

简介:喹喔啉在药物化学领域显示出多种应用。

材料和方法:因此,我们设计了一种高效,环境友好的一锅法实验方案,用于在甘油-水中超声照射下苯乙酮,N-溴琥珀酰亚胺和1,2-苯二胺的反应合成2-苯基喹喔啉。

结果与讨论:我们观察到,尽管在所有这些溶剂中都能有效地完成反应,但使用不同比例的甘油-水可始终如一地提高产率(89-94%)并缩短反应时间。

结论:该方案的主要优点是它是一种绿色方法,避免使用有毒催化剂和挥发性有机介质,且收率高。

更新日期:2020-09-25
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