Double gloving of disposable gloves is now commonplace in healthcare settings when extra protection is needed against aqueous solutions and especially for antineoplastic drugs in isotonic aqueous media. In the present study, an ASTM F739 2.54 cm cell with closed-loop water collection without recirculation at 35 °C in a moving tray water bath was used to test the permeation of diethylene glycol mono-n-butyl ether (DGBE) through four types of disposable nitrile gloves that were singly and doubly layered in the permeation cell. Samples were taken over 8 hr for capillary gas chromatograph-mass spectrometer quantitation. The breakthrough time (t_n) at a permeation of 250 ng/cm² increased as thickness increased for single layers, but the steady-state permeation rates P_s in µg/cm²/min did not always decrease with increasing thickness. The double-layer t_n, P_s and thickness were also more variable relative to a single layer. The thinnest glove with 80 $\mathrm{\mu }$m thickness showed a t_n = 0–5 min whereas its double layer was 15–20 min. The thickest glove of 132 µm exhibited a t_n = 10–15 min but its double layer was t_n = 45–55 min. The adjusted double-layer average t_n divided by the adjusted single-layer average t_n was 4.0 ± 0.8. The adjusted average single-layer P_s divided by the adjusted average double-layer P_s was 3.5 ± 0.8. Other results showed that the average glove swelling was <10%; microscopic and leak testing indicated no penetration and reflectance infrared analysis also showed no chemical changes on the inside glove surfaces. Thus, the permeations were adjudged to obey Fick’s First Law of Diffusion to allow calculation of diffusion coefficients D in cm²/min. The average single-layer D divided by the average double-layer D was 1.3 ± 0.2. Double gloving in the field is therefore also probably more protective than single gloving against DGBE for the four types of disposable nitrile gloves tested.

当需要额外的水溶液防护，尤其是等渗水性介质中的抗肿瘤药物时，一次性手套的双手套在医疗机构中很普遍。在本研究中，使用ASTM F739 2.54 cm闭路集水槽，在移动托盘水浴中在35°C下不进行再循环的情况下，用于测试二种类型的二甘醇单正丁基醚（DGBE）的渗透一次性丁腈手套，它们在渗透池中单层和双层。在8小时内取样品用于毛细管气相色谱-质谱仪定量。单层的厚度增加时，渗透率为250 ng / cm ²时的穿透时间（t _n）会增加，但稳态渗透率P _s以µg / cm ² / min为单位的值并不总是随厚度的增加而减小。相对于单层，双层t _n，P _s和厚度也更具可变性。最薄的手套80 $\mathrm{\mu }$m厚度显示在_n = 0-5分钟，而其双层为15-20分钟。厚度最大的132 µm手套在_n = 10–15分钟时出现，但其双层为t _n = 45–55分钟。调整后的双层平均值t _n除以调整后的单层平均值t _n为4.0±0.8。调整后的平均单层P _s除以调整后的平均双层P _s为3.5±0.8。其他结果表明，平均手套肿胀率小于10％。显微镜和泄漏测试表明没有穿透和反射红外分析也表明手套内表面没有化学变化。因此，将渗透率判定为服从菲克的第一扩散定律，以计算以cm ² / min为单位的扩散系数D。平均单层D除以平均双层D为1.3±0.2。因此，对于四种类型的一次性丁腈手套，在现场使用双手套也可能比用DGBE戴单手套更具防护性。