Group 2 innate lymphoid cells (ILC2s) are type 2 cytokine-producing cells that have important roles in helminth infection and allergic inflammation. ILC2s are tissue-resident cells, and their phenotypes and roles are regulated by tissue-specific environmental factors. While the role of ILC2s in the lung, intestine and bone marrow has been elucidated in many studies, their role in adipose tissues is still unclear. Here, we report on the role of ILC2-derived bone morphogenetic protein 7 (BMP7) in adipocyte differentiation and lipid accumulation. Co-culture of fat-derived ILC2s with pluripotent mesenchymal C3H10T1/2 cells and committed white preadipocyte 3T3-L1 cells resulted in their differentiation to adipocytes and induced lipid accumulation. Co-culture experiments using BMP7-deficient ILC2s revealed that BMP7, produced by ILC2s, induces differentiation into brown adipocytes. Our results demonstrate that BMP7, produced by ILC2s, affects adipocyte differentiation, particularly in brown adipocytes.

中文翻译：

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第2组先天性淋巴样细胞产生的BMP7对脂肪形成的影响。

第2组先天淋巴样细胞（ILC2s）是产生2型细胞因子的细胞，在蠕虫感染和过敏性炎症中具有重要作用。ILC2是组织驻留细胞，其表型和作用受组织特异性环境因素调控。尽管在许多研究中已经阐明了ILC2在肺，肠和骨髓中的作用，但它们在脂肪组织中的作用仍不清楚。在这里，我们报告ILC2衍生的骨形态发生蛋白7（BMP7）在脂肪细胞分化和脂质蓄积中的作用。脂肪来源的ILC2与多能间充质C3H10T1 / 2细胞和定型的白色前脂肪细胞3T3-L1细胞共培养导致它们分化为脂肪细胞并诱导脂质蓄积。使用缺乏BMP7的ILC2进行的共培养实验表明，ILC2产生的BMP7 诱导分化为褐色脂肪细胞。我们的结果表明，ILC2s产生的BMP7会影响脂肪细胞的分化，特别是在棕色脂肪细胞中。