First synthesis of the diastereomeric mixture of salbutamol impurity F is described in seven steps by using 4-hydroxyacetophenone as starting material, with 15.2% total yield. The synthesis provides access to multi-gram quantities of impurity F with good purity for reference supplies and further analytical and toxicology investigations.

中文翻译：

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沙丁胺醇杂质F的合成。

沙丁胺醇杂质F的非对映异构体混合物的首次合成以7个步骤描述，该方法以4-羟基苯乙酮为起始原料，总收率为15.2％。该合成方法可提供数克量的纯度良好的杂质F，以作参考供应以及进一步的分析和毒理学研究。