We performed a systematic review and meta-analysis of randomized controlled trials (RCTs) to assess the effects of magnesium (Mg) supplementation on the lipid profile in type 2 diabetes (T2DM) patients. Web of Science, Scopus, PubMed, and Embase databases were searched to infinity until 30 January 2020. Weighted mean differences (WMD) were pooled using a random-effects model. Heterogeneity, sensitivity analysis, and publication bias were reported using standard methods. The pooled analysis of 12 randomized controlled trials indicated that Mg administration led to significant reduction of serum low-density lipoprotein (LDL) levels (p = 0.006). However, our results revealed that Mg supplementation did not have any effect on triglycerides (TG), total cholesterol (TC), and high-density lipoprotein (HDL) serum concentrations among T2DM patients in comparison with the control group. Subgroup analysis based on duration of study suggested that more than 12 weeks of Mg supplementation significantly decreased the serum TC levels (p = 0.002). Subgroup analysis comparing the dose of intervention indicated that Mg supplementation less than 300 mg significantly decreased the serum LDL concentrations (p < 0.001), while more than 300 mg of Mg supplementation significantly increased the serum HDL levels (p = 0.026). In a subgroup analysis comparing the type of intervention, it displayed that inorganic Mg supplementation decreased the LDL (p < 0.001) and TC (p = 0.003) levels, while organic Mg supplementation showed no difference. Mg supplementation has a beneficial effect on lowering LDL level in T2DM patients. However, we have to note that any research performed so far is not sufficient for making robust guidelines to use Mg supplementation in clinical practice.

我们对随机对照试验（RCT）进行了系统的回顾和荟萃分析，以评估补充镁（Mg）对2型糖尿病（T2DM）患者血脂的影响。搜索Web of Science，Scopus，PubMed和Embase数据库直至无限，直到2020年1月30日。使用随机效应模型汇总加权均数差（WMD）。使用标准方法报告了异质性，敏感性分析和出版物偏倚。对12项随机对照试验的汇总分析表明，服用Mg可显着降低血清低密度脂蛋白（LDL）水平（p = 0.006）。但是，我们的结果表明，与对照组相比，补充Mg对T2DM患者的甘油三酸酯（TG），总胆固醇（TC）和高密度脂蛋白（HDL）血清浓度没有任何影响。根据研究持续时间进行的亚组分析表明，补充镁超过12周会显着降低血清TC水平（p  = 0.002）。对干预剂量进行的亚组分析表明，少于300 mg的补充镁可显着降低血清LDL浓度（p  <0.001），而大于300 mg的Mg补充可显着提高血清HDL水平（p = 0.026）。在比较干预类型的亚组分析中，研究表明，无机镁的添加降低了LDL（p  <0.001）和TC（p  = 0.003）的水平，而有机镁的添加则没有差异。补充镁可降低T2DM患者的LDL水平。但是，我们必须指出，迄今为止进行的任何研究都不足以为在临床实践中使用镁补充剂制定可靠的指南提供足够的指导。