Oral tablets with tunable release profiles have emerged to enhance the effectiveness of therapies in different clinical conditions. Although the concept of tablets with adjustable release profiles has been studied before, the lack of a fast and scalable production technique has limited their widespread application. In this study, a scalable fabrication method was developed to manufacture controlled-release polyanhydride tablets. A new polymeric core–shell tablet design is also proposed, that in conjunction with a micro-fabrication procedure, allows for achieving tunable release profiles required in personalized medicine in small-size tablets. Utilizing a surface-erodible polymeric carrier in the fabrication of the new tablet design resulted in achieving adjustable release profiles and improvements in the drug-loading capacity of the delivery system which allows for delivering a flexible amount of therapeutics with desirable patterns to patients. The proposed fabrication techniqu...

中文翻译：

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由具有可调释放曲线的单一易蚀聚合物可扩展地制备载药核壳片剂。

具有可调释放曲线的口服片剂已经出现，以增强在不同临床条件下治疗的有效性。尽管之前已经研究了具有可调释放曲线的片剂的概念，但是缺乏快速和可扩展的生产技术限制了其广泛的应用。在这项研究中，开发了可扩展的制造方法来制造控释聚酸酐片剂。还提出了一种新的聚合物核-壳片剂设计，该设计与微细加工程序相结合，可实现小型片剂个性化药物所需的可调释放曲线。在新的片剂设计中使用可表面腐蚀的聚合物载体可实现可调节的释放特性，并改善了输送系统的载药量，从而可以向患者输送所需量的具有理想模式的柔性治疗剂。拟议的制造技术...