New psychoactive substances (NPS) have become a serious public health problem, as they are continuously changing their structures and modifying their potency and effects on humans, and therefore, novel compounds are unceasingly appearing. One of the major challenges in forensic analysis, particularly related to the problem of NPS, is the development of fast screening methodologies that allow the detection of a wide variety of compounds in a single analysis. In this study, a novel application of the atmospheric solids analysis probe (ASAP) using medical swabs has been developed. The swab-ASAP was coupled to a triple quadrupole mass analyzer working under a data-dependent acquisition mode in order to perform a suspect screening of NPS in different types of samples as well as on surfaces. The compounds were automatically identified based on the observed fragmentation spectra using an in-house built MS/MS spectra library. The developed methodology was applied for the identification of psychoactive substances in research chemicals and herbal blends. The sensitivity of the method, as well as its applicability for surface analysis, was also assessed by identifying down to 1 μg of compound impregnated onto a laboratory table. Another remarkable application was the identification of cathinones and synthetic cannabinoids on the fingers of potential consumers. Interestingly, our data showed that NPS could be identified on the fingers after being in contact with the product and even after cleaning their hands by shaking off with a cloth. The methodology proposed in this paper can be applied for routine analyses of NPS in different matrix samples without the need to establish a list of target compounds prior to analysis.

中文翻译：

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使用药物拭子和大气固体分析直接快速筛查新的精神活性物质，并根据数据获取三重四极杆。

新的精神活性物质（NPS）不断改变其结构并改变其对人类的效力和影响，已成为一个严重的公共卫生问题，因此，新化合物不断出现。法医分析（尤其是与NPS问题有关）的主要挑战之一是快速筛选方法的发展，该方法可在一次分析中检测多种化合物。在这项研究中，已开发出使用医用拭子的大气固体分析探针（ASAP）的新应用。拭子-ASAP与在数据依赖的采集模式下工作的三重四极杆质量分析仪相连，以便对不同类型的样品以及表面上的NPS进行可疑的筛选。使用内部建立的MS / MS光谱库，根据观察到的碎片光谱自动识别化合物。所开发的方法应用于鉴定研究化学品和草药混合物中的精神活性物质。该方法的灵敏度及其在表面分析中的适用性也通过鉴定低至1μg浸渍在实验室工作台上的化合物来评估。另一个引人注目的应用是在潜在消费者的手指上鉴定卡西酮和合成大麻素。有趣的是，我们的数据表明，与产品接触后，甚至通过用布摇晃来清洁双手后，手指上都可以识别出NPS。