BACKGROUND Tissue growth over covered branches is a leading cause of delayed thrombotic complications after flow-diverter stenting (FDS). Due to insufficient resolution, no imaging modality is clinically available to monitor this phenomenon. OBJECTIVE To evaluate high-frequency optical coherence tomography (HF-OCT), a novel intravascular imaging modality designed for the cerebrovascular anatomy with a resolution approaching 10 microns, to monitor tissue growth over FDS in an arterial bifurcation model. METHODS FDS were deployed in a rabbit model (n = 6), covering the aortic bifurcation. The animals were divided in different groups, receiving dual antiplatelet therapy (DAPT) (n = 4), aspirin only (n = 1), and no treatment (n = 1). HF-OCT data were obtained in vivo at 3 different time points in each animal. For each cross-sectional image, metal and tissue coverage of the jailed ostium was quantified. Scanning electron microscopy images of harvested arteries were subsequently obtained. RESULTS Good quality HF-OCT data sets were successfully acquired at implant and follow-up. A median value of 41 (range 21-55) cross-sectional images were analyzed per ostium for each time point. Between 0 and 30 d after implant, HF-OCT analysis showed a significantly higher ostium coverage when DAPT was not given. After 30 d, similar growth rates were found in the DAPT and in the aspirin group. At 60 d, a coverage of 90% was reached in all groups. CONCLUSION HF-OCT enables an accurate visualization of tissue growth over time on FDS struts. The use of FDS in bifurcation locations may induce a drastic reduction of the jailed-branch ostium area.

中文翻译：

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使用神经血管高频光学相干断层扫描对分叉模型中植入后的分流支架组织覆盖进行纵向监测


背景技术覆盖分支上的组织生长是分流器支架置入术(FDS)后迟发性血栓形成并发症的主要原因。由于分辨率不足，临床上没有可用的成像方式来监测这种现象。目的 评估高频光学相干断层扫描 (HF-OCT)，这是一种专为脑血管解剖结构设计的新型血管内成像方式，分辨率接近 10 微米，可通过 FDS 监测动脉分叉模型中的组织生长。方法 FDS 部署在兔子模型（n = 6）中，覆盖主动脉分叉处。将动物分为不同组，接受双重抗血小板治疗（DAPT）（n = 4）、仅接受阿司匹林（n = 1）和不接受治疗（n = 1）。每只动物体内 3 个不同时间点获得 HF-OCT 数据。对于每个横截面图像，对被监禁口的金属和组织覆盖进行了量化。随后获得了收获动脉的扫描电子显微镜图像。结果 在植入和随访时成功获取了高质量的 HF-OCT 数据集。每个时间点对每个口分析 41 张（范围 21-55）横截面图像的中值。植入后 0 至 30 天之间，HF-OCT 分析显示，未给予 DAPT 时，开口覆盖率显着较高。 30 天后，DAPT 组和阿司匹林组的生长速度相似。 60天时，所有组的覆盖率均达到90%。结论 HF-OCT 能够准确地可视化 FDS 支柱上组织随时间的生长情况。在分叉位置使用 FDS 可能会导致监狱分支口面积大幅减少。