The current pandemic caused by severe acute respiratory syndrome coronavirus (SARS-CoV)-2 has created an unparalleled health crisis. Besides the acute respiratory infection, CoVs are neuroinvasive causing additional inflammation and neurodegeneration. This is likely also true of SARS-CoV-2 given reports of neurological manifestations in coronavirus disease 2019 (COVID-19) positive patients. Older adults > 65 years of age constitute a high-risk group prone to severe infection and death. Despite the higher mortality rate, a majority of cases are expected to recover and survive from this viral outbreak. But, the long-term consequences of SARS-CoV-2 neuroinfection are unknown. We discuss these potential chronic changes to the central nervous system (CNS) in relation to accelerated brain aging and age-related neurodegenerative disorders.

中文翻译：

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SARS-CoV-2 感染会导致慢性神经系统并发症吗？


当前由严重急性呼吸综合征冠状病毒（SARS-CoV）-2引起的大流行造成了前所未有的健康危机。除了急性呼吸道感染外，冠状病毒还具有神经侵袭性，会导致额外的炎症和神经变性。鉴于 2019 年冠状病毒病 (COVID-19) 阳性患者神经系统表现的报道，SARS-CoV-2 也可能如此。 65岁以上老年人是容易发生严重感染和死亡的高危人群。尽管死亡率较高，但大多数病例预计会从这次病毒爆发中康复并存活下来。但是，SARS-CoV-2 神经感染的长期后果尚不清楚。我们讨论了中枢神经系统（CNS）的这些潜在慢性变化与大脑加速老化和与年龄相关的神经退行性疾病的关系。