Gymnema sylvestre, a plant typical of India, has long been known for its hypoglycemic effects. The objective of this study was to evaluate the effect of G. sylvestre administration on glycemic control, insulin secretion, and insulin sensitivity in patients with impaired glucose tolerance (IGT). A randomized, double-blind, placebo-controlled clinical trial was conducted in 30 patients with IGT. Fifteen patients randomly received G. sylvestre in doses of 300 mg b.i.d. and the other 15 received placebo in the same way. Before and after the intervention, anthropometric and metabolic measurements were taken, including 2-h oral glucose tolerance test (2-h OGTT), fasting plasma glucose, glycated hemoglobin A1c (A1C), and the lipid profile panel. Areas under the curve of glucose and insulin were calculated, as well as the insulinogenic, Stumvoll, and Matsuda indices. Wilcoxon, Mann–Whitney U, and chi-square or Fisher's exact tests were performed, and a P-value ≤.05 was considered statistically significant. There was a significant reduction in 2-h OGTT (9.1 ± 1.2 vs. 7.8 ± 1.7 mmol/L, P = .003), A1C (5.8 ± 0.3% vs. 5.4 ± 0.4%, P = .025), body weight, body mass index, and low-density lipoprotein cholesterol levels in the G. sylvestre group, with an increment in the Matsuda index (1.8 ± 0.8 vs. 2.4 ± 1.2, P = .008). At the end of the intervention, 46.7% of the patients obtained normal values in A1C. In conclusion, G. sylvestre administration in patients with IGT decreased 2-h OGTT and A1C, increasing insulin sensitivity. There were also improvements in anthropometric measures and the lipid profile.

中文翻译：

---

实施匙Gym藤对糖耐量减低患者的血糖控制，胰岛素分泌和胰岛素敏感性的影响。

Gymnema sylvestre是印度典型的植物，长期以来因其降血糖作用而闻名。这项研究的目的是评估在糖耐量减低（IGT）患者中服用G.sylvestr e对血糖控制，胰岛素分泌和胰岛素敏感性的影响。在30例IGT患者中进行了一项随机，双盲，安慰剂对照的临床试验。15例患者随机接受樟子松以300 mg bid的剂量服用，其余15剂以相同方式接受安慰剂。干预前后，进行人体测量和代谢测量，包括2小时口服葡萄糖耐量测试（2小时OGTT），空腹血糖，糖化血红蛋白A1c（A1C）和脂质谱图。计算了葡萄糖和胰岛素曲线下的面积，以及致胰岛素指数，Stumvoll和Matsuda指数。进行了Wilcoxon，Mann-Whitney U和卡方检验或Fisher精确检验，并且P值≤.05被认为具有统计学意义。2小时OGTT（9.1±1.2 vs. 7.8±1.7 mmol / L，P  = .003），A1C显着降低（5.8±0.3％vs. 5.4±0.4％，PG. sylvestre组的 体重，体重指数和低密度脂蛋白胆固醇水平，而松田指数则有所增加（1.8±0.8对2.4±1.2，P  = 0.008）。干预结束时，有46.7％的患者获得了A1C的正常值。总之，G.西尔韦斯特患者施用与IGT降低2小时OGTT和A1C，增加胰岛素敏感性。人体测量指标和血脂水平也有所改善。