OBJECTIVES Periostin is secreted from the placenta in the embryonic period and it is emphasized that it may be involved in endometrial implantation. In this study, we aimed to investigate periostin serum levels and placental tissue expression in first trimester pregnancy losses. STUDY DESIGN In this prospective case-control study, 30 patients who underwent dilatation and curettage with first trimester spontaneous abortion (<10 weeks of gestation) were included in the study group and 30 patients who had voluntary pregnancy termination (<10 gestational weeks) were included in the control group. Serum samples collected from the study and control groups were analyzed usingenzyme-linkedimmunosorbent assay (ELISA), and trophoblastic and decidual tissues were examined using immunohistochemical staining with streptavidin-biotin-peroxidase techniques. RESULTS There were no significant differences between the groups in terms of age, gravida status, parity number, gestational week, and number of previous abortions. In the spontaneous abortion group, the serum level of periostin was significantly lower than in the voluntary termination group (6.56 ± 4.16 pg/mLvs. 9.51 ± 4.52 pg/mL, p = 0.03). There was no significant difference between the two groups in terms of periostin expression in decidual and trophoblastic tissue (p = 0.617, p = 0.274, p = 0.497). CONCLUSION Periostin serum levels were significantly reduced in patients with spontaneous pregnancy loss. Periostin can be used as a predictive marker for the success of endometrial implantation.

中文翻译：

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早期流产妇女的血清和胎盘骨膜素水平。

目的 Periostin 在胚胎期从胎盘分泌，强调它可能参与子宫内膜植入。在这项研究中，我们旨在调查早孕期流产中骨膜蛋白的血清水平和胎盘组织的表达。研究设计 在这项前瞻性病例对照研究中，研究组包括 30 名接受扩张和刮宫术的妊娠早期自然流产（<10 孕周）和 30 名自愿终止妊娠（<10 孕周）的患者。纳入对照组。使用酶联免疫吸附试验 (ELISA) 分析从研究组和对照组收集的血清样品，使用免疫组织化学染色和链霉亲和素-生物素-过氧化物酶技术检查滋养细胞和蜕膜组织。结果 各组在年龄、妊娠状态、产次数、孕周和既往流产次数方面无显着差异。在自然流产组中，骨膜蛋白的血清水平显着低于自愿终止组（6.56 ± 4.16 pg/mLvs. 9.51 ± 4.52 pg/mL，p = 0.03）。在蜕膜组织和滋养层组织中骨膜蛋白表达方面，两组之间没有显着差异（p = 0.617，p = 0.274，p = 0.497）。结论自发性流产患者的骨膜蛋白血清水平显着降低。Periostin 可用作子宫内膜植入成功的预测标志物。结果 各组在年龄、妊娠状态、产次数、孕周和既往流产次数方面无显着差异。在自然流产组中，骨膜蛋白的血清水平显着低于自愿终止组（6.56 ± 4.16 pg/mLvs. 9.51 ± 4.52 pg/mL，p = 0.03）。在蜕膜组织和滋养层组织中骨膜蛋白表达方面，两组之间没有显着差异（p = 0.617，p = 0.274，p = 0.497）。结论自发性流产患者的骨膜蛋白血清水平显着降低。Periostin 可用作子宫内膜植入成功的预测标志物。结果 各组在年龄、妊娠状态、产次数、孕周和既往流产次数方面无显着差异。在自然流产组中，骨膜蛋白的血清水平显着低于自愿终止组（6.56 ± 4.16 pg/mLvs. 9.51 ± 4.52 pg/mL，p = 0.03）。在蜕膜组织和滋养层组织中骨膜蛋白表达方面，两组之间没有显着差异（p = 0.617，p = 0.274，p = 0.497）。结论自发性流产患者的骨膜蛋白血清水平显着降低。Periostin 可用作子宫内膜植入成功的预测标志物。在自然流产组中，骨膜蛋白的血清水平显着低于自愿终止组（6.56 ± 4.16 pg/mLvs. 9.51 ± 4.52 pg/mL，p = 0.03）。在蜕膜组织和滋养层组织中骨膜蛋白表达方面，两组之间没有显着差异（p = 0.617，p = 0.274，p = 0.497）。结论自发性流产患者的骨膜蛋白血清水平显着降低。Periostin 可用作子宫内膜植入成功的预测标志物。在自然流产组中，骨膜蛋白的血清水平显着低于自愿终止组（6.56 ± 4.16 pg/mLvs. 9.51 ± 4.52 pg/mL，p = 0.03）。在蜕膜组织和滋养层组织中骨膜蛋白表达方面，两组之间没有显着差异（p = 0.617，p = 0.274，p = 0.497）。结论自发性流产患者的骨膜蛋白血清水平显着降低。Periostin 可用作子宫内膜植入成功的预测标志物。p = 0.274，p = 0.497）。结论自发性流产患者的骨膜蛋白血清水平显着降低。Periostin 可用作子宫内膜植入成功的预测标志物。p = 0.274，p = 0.497）。结论自发性流产患者的骨膜蛋白血清水平显着降低。Periostin 可用作子宫内膜植入成功的预测标志物。