Earlier data suggest a relationship between PIBF concentrations and the outcome of pregnancy. The aim of the study was to compare serum and urine concentrations of PIBF in women with successful pregnancy after IVF with those of women without pregnancy after IVF procedure, and to evaluate the potential relation between PIBF and the outcome of pregnancy. Urine and serum were collected from 120 women, undergoing IVF. 87.5% of patients had primary infertility. 69.2% faced female causes of infertility: 10.8% tubal cause, 11.7% ovulation disorder, and 46.7% other causes of infertility. 30.8% of patients had male factor of infertility. Among non-pregnant women (42) mean concentrations of PIBF in urine and serum were significantly lower (15.8 ng/mL; 148.4 ng/mL) than in women with positive beta HCG value (78) (19.1 ng/mL; 225.9 ng/mL). In 49 patients pregnancy terminated with a term delivery, in 10 patients with pretem delivery, while in 19 patients the pregnancy terminated with a miscarriage. PIBF concentrations in urine (13.9 ± 2.8 ng/mL) and serum (124.6 ± 46.7 ng/mL) samples of women with miscarriage were significantly lower of those with preterm delivery (180.6 ± 54.4 ng/mL; 18.1 ± 4.4 ng/mL) and of those with term delivery (20.4 ± 8.5 ng/mL; 208.7 ± 114.3 ng/mL). Successful pregnancy after IVF procedure is predictable by measuring of urine and serum PIBF concentrations and could be important for predicting of early implantation and pregnancy outcome after IVF procedure and maybe to protect the risk pregnancy.

中文翻译：

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孕早期服用的孕酮诱导阻断因子 (PIBF) 可预测接受体外受精手术的女性的妊娠结局。

早期的数据表明 PIBF 浓度与妊娠结果之间存在关系。该研究的目的是比较 IVF 后成功怀孕的女性与 IVF 后未怀孕女性的 PIBF 血清和尿液浓度，并评估 PIBF 与妊娠结局之间的潜在关系。收集了 120 名接受试管婴儿的女性的尿液和血清。87.5%的患者有原发性不孕症。69.2% 面临女性不孕原因：10.8% 输卵管原因，11.7% 排卵障碍，46.7% 其他原因导致不孕。30.8%的患者有男性不育因素。在非孕妇 (42) 中，尿液和血清中 PIBF 的平均浓度 (15.8 ng/mL; 148.4 ng/mL) 显着低于具有阳性 β HCG 值的女性 (78) (19.1 ng/mL; 225.9 ng/mL)毫升）。49 名患者因足月分娩而终止妊娠，10 名患者因早产而终止，而 19 名患者因流产而终止妊娠。流产妇女的尿液 (13.9 ± 2.8 ng/mL) 和血清 (124.6 ± 46.7 ng/mL) 样本中的 PIBF 浓度显着低于早产妇女 (180.6 ± 54.4 ng/mL; 18.1 ± 4.4 ng/mL)和足月分娩者（20.4 ± 8.5 ng/mL；208.7 ± 114.3 ng/mL）。通过测量尿液和血清 PIBF 浓度可以预测 IVF 手术后的成功怀孕，这对于预测 IVF 手术后的早期植入和妊娠结果很重要，并可能保护风险妊娠。流产妇女的尿液 (13.9 ± 2.8 ng/mL) 和血清 (124.6 ± 46.7 ng/mL) 样本中的 PIBF 浓度显着低于早产妇女 (180.6 ± 54.4 ng/mL; 18.1 ± 4.4 ng/mL)和足月分娩者（20.4 ± 8.5 ng/mL；208.7 ± 114.3 ng/mL）。通过测量尿液和血清 PIBF 浓度可以预测 IVF 手术后的成功怀孕，这对于预测 IVF 手术后的早期植入和妊娠结果很重要，并可能保护风险妊娠。流产妇女的尿液 (13.9 ± 2.8 ng/mL) 和血清 (124.6 ± 46.7 ng/mL) 样本中的 PIBF 浓度显着低于早产妇女 (180.6 ± 54.4 ng/mL; 18.1 ± 4.4 ng/mL)和足月分娩者（20.4 ± 8.5 ng/mL；208.7 ± 114.3 ng/mL）。通过测量尿液和血清 PIBF 浓度可以预测 IVF 手术后的成功怀孕，这对于预测 IVF 手术后的早期植入和妊娠结果很重要，并可能保护风险妊娠。