Alcohol use disorder (AUD) and posttraumatic stress disorder (PTSD) frequently co-occur, highlighting the importance of understanding the etiology of these comorbid conditions. Although AUD and PTSD are moderately heritable with modest overlap in genetic risk as estimated from family studies, there has been a paucity of work using molecular genetic data to estimate shared genetic effects on these conditions. This study used large-scale genomewide molecular data to examine shared genetic risk for AUD, specifically alcohol dependence (AD), and PTSD through cross-trait linkage disequilibrium (LD) score regression (LDSC; also known as LDSR). Summary statistics came from the Psychiatric Genomics Consortium (PGC) PTSD Workgroup Freeze 2 European ancestry (EA) participants (N = 174,659) and AD summary statistics in EA participants (N = 38,686) came from the PGC Substance Use Disorders (SUD) Workgroup. We performed LDSC to estimate genetic correlation between AD and PTSD using HapMap3 variants and LD scores from the 1000 Genomes project. A moderate, significant correlation was observed between AD and PTSD (rg = .35, p = .02), with sex differences identified through stratified analyses. Our results are the first to demonstrate evidence of a shared molecular genetic etiology for AD and PTSD. Further research is needed to better understand possible sex differences in shared heritability and extend these results to additional populations. (PsycINFO Database Record (c) 2020 APA, all rights reserved).

中文翻译：

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酒精依赖和创伤后应激障碍（PTSD）的共同分子遗传风险。


酒精使用障碍 (AUD) 和创伤后应激障碍 (PTSD) 经常同时发生，凸显了了解这些共病病因的重要性。尽管根据家庭研究估计，AUD 和 PTSD 具有中等程度的遗传性，并且遗传风险有适度的重叠，但利用分子遗传数据来估计这些疾病的共同遗传影响的工作却很少。本研究使用大规模全基因组分子数据，通过跨性状连锁不平衡 (LD) 评分回归 (LDSC；也称为 LDSR) 来检查 AUD 的共同遗传风险，特别是酒精依赖 (AD) 和 PTSD。摘要统计数据来自精神病基因组学联盟 (PGC) PTSD 工作组 Freeze 2 欧洲血统 (EA) 参与者 (N = 174,659)，EA 参与者 (N = 38,686) 的 AD 摘要统计数据来自 PGC 药物使用障碍 (SUD) 工作组。我们使用 HapMap3 变体和来自 1000 Genomes 项目的 LD 分数进行 LDSC 来估计 AD 和 PTSD 之间的遗传相关性。 AD 和 PTSD 之间观察到中等、显着的相关性（rg = .35，p = .02），通过分层分析确定了性别差异。我们的研究结果首次证明 AD 和 PTSD 具有共同的分子遗传学病因。需要进一步的研究来更好地了解共享遗传力中可能存在的性别差异，并将这些结果扩展到更多人群。 （PsycINFO 数据库记录 (c) 2020 APA，保留所有权利）。