Abstract

Idiopathic pulmonary fibrosis (IPF) is a fatal lung disease characterized by interstitial remodeling, leading to compromised lung function. Extra vascular fibrin deposition and abnormalities in the fibrinolysis are the major clinical manifestations of lung diseases such as acute lung injury (ALI) and its most severe form, acute respiratory distress syndrome (ARDS). ALI progresses to pulmonary fibrosis (PF) and makes patient’s life miserable. Anti-fibrinolysis and apoptosis are involved in the progression of PF. Apoptotic markers are detectable within IPF lung tissue and senescent cell deletion can rejuvenate pulmonary health. Enhanced expression of p53 due to DNA damage is seen in irradiated lung tissue. The role of fibrinolytic components such as Urokinase Plasminogen activator (uPA), uPA receptor (uPAR) and Plasminogen activator inhibitor-1 (PAI-1) has been detailed in I. Curcumin is known to possess anti-inflammatory and anti-fibrotic effects. Radioprotective effect of curcumin enables it to attenuate radiation-induced inflammation and fibrosis. Understanding the mechanism of radioprotective effect of curcumin in radiation-induced PF and apoptosis can lead to the development of an effective therapeutic to combat acute lung injury and fibrosis.

摘要

特发性肺纤维化（IPF）是一种致命的肺部疾病，其特征是间质重塑，导致肺功能受损。额外的血管纤维蛋白沉积和纤维蛋白溶解异常是肺部疾病的主要临床表现，例如急性肺损伤（ALI）及其最严重的形式即急性呼吸窘迫综合征（ARDS）。ALI会发展为肺纤维化（PF），使患者的生活痛苦不堪。抗纤维蛋白溶解和细胞凋亡与PF的进展有关。在IPF肺组织中可检测到凋亡标志物，而衰老细胞的缺失可恢复肺部健康。在辐射的肺组织中观察到由于DNA损伤而导致的p53表达增强。纤溶成分的作用，例如尿激酶纤溶酶原激活剂（uPA），I中已经详细描述了uPA受体（uPAR）和纤溶酶原激活物抑制剂1（PAI-1）。姜黄素已知具有抗炎和抗纤维化作用。姜黄素的辐射防护作用使其能够减轻辐射引起的炎症和纤维化。了解姜黄素对辐射诱发的PF和细胞凋亡的辐射防护作用机理，可以导致开发出一种有效的治疗急性肺损伤和纤维化的药物。