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Proinflammatory Cytokines Are Modulated in Vietnamese Patients with Dengue Fever.
Viral Immunology ( IF 1.5 ) Pub Date : 2020-09-01 , DOI: 10.1089/vim.2020.0023
Tran Thi Tuyen 1, 2 , Nguyen Thanh Viet 3 , Ngo Thu Hang 1, 4 , Ngo Truong Giang 1, 5 , Do Duc Anh 3 , Do Tuan Anh 6 , Hoang Vu Hung 6 , Do Quyet 6 , Nguyen Linh Toan 1 , Truong Dinh Cam 7 , Hoang Van Tong 1, 3
Affiliation  

The clinical outcome of dengue is due to a complex interplay between dengue virus (DENV) and host immune factors, including complement and cytokine systems. Proinflammatory cytokines are mainly produced by monocytes in response to infectious pathogens. This study investigated the levels of proinflammatory cytokines, including tumor necrosis factor-α (TNF-α), interleukin-1 beta (IL-1β), and IL-12 in Vietnamese patients with dengue, and their correlations with the clinical outcome of dengue infection in 156 patients clinically classified as dengue without warning signs (DWS−, n = 87), dengue with warning signs (DWS+, n = 62), and severe dengue (SD, n = 7) patients as well as in 60 healthy controls (HCs). Serum TNF-α, IL-1β, and IL-12 levels were quantified by enzyme-linked immunosorbent assay (ELISA). The results showed that TNF-α, IL-1β, and IL-12 levels were significantly increased in dengue patients compared with HCs (p < 0.0001). TNF-α levels were significantly correlated with white blood cells and platelet counts (rs = 0.52, 0.2; p < 0.0001, p = 0.018, respectively). IL-1β levels were correlated with red blood cells counts and the levels of aspartate aminotransferase and alanine aminotransferase (rs = 0.23, 0.21, 0.23; p = 0.004, 0.012, 0.005, respectively). The results suggest that these three proinflammatory cytokines are associated with the clinical outcome of dengue and could play roles in the pathogenesis of the disease.

中文翻译:

越南登革热患者的促炎细胞因子受到调节。

登革热的临床结果是由于登革热病毒 (DENV) 与宿主免疫因子(包括补体和细胞因子系统)之间复杂的相互作用。促炎细胞因子主要由单核细胞对感染性病原体产生反应。本研究调查了越南登革热患者体内促炎细胞因子的水平,包括肿瘤坏死因子-α (TNF-α)、白细胞介素-1β (IL-1β) 和 IL-12,以及它们与登革热临床结果的相关性。 156 名临床分类为无预警信号登革热 (DWS-, n  = 87)、有预警信号登革热 (DWS+, n  = 62) 和重度登革热 (SD, n = 7) 患者以及 60 名健康对照 (HC)。血清 TNF-α、IL-1β 和 IL-12 水平通过酶联免疫吸附测定 (ELISA) 进行定量。结果显示,与 HCs 相比,登革热患者的 TNF-α、IL-1β 和 IL-12 水平显着升高(p  < 0.0001)。TNF-α 水平与白细胞和血小板计数显着相关(分别为r s  = 0.52、0.2;p  < 0.0001、p  = 0.018)。IL-1β 水平与红细胞计数以及天冬氨酸氨基转移酶和丙氨酸氨基转移酶水平相关 ( r s  = 0.23, 0.21, 0.23; p = 0.004、0.012、0.005)。结果表明,这三种促炎细胞因子与登革热的临床结果相关,并可能在该病的发病机制中发挥作用。
更新日期:2020-09-05
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